Warfarin Drug Interactions


4.6 out of 5 (33 Reviews)



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Start Date

1 Jan 2023

Last Review Date

1 May 2023

Expiration Date

31 Dec 2025

Estimated Time To Finish

90 Minutes

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Activity Description

Warfarin has FDA approval for the prophylaxis and treatment of venous thrombosis and its complications, such as a pulmonary embolus. It is also indicated to prevent thromboembolic complications associated with conditions such as atrial fibrillation, cardiac valve replacement, and inherited genetic factors like C and S protein deficiency or Factor V Leiden. Additionally, warfarin is FDA approved as an adjunct to reduce the risk of myocardial infarction (MI) and other thromboembolic events in high-risk patients. However, warfarin falls in the narrow therapeutic index drug category and is subject to numerous interactions. This activity outlines the indications, mechanism of action, interactions, significant adverse effects, contraindications, toxicity, and warfarin monitoring so providers can direct patient therapy where anticoagulation is indicated as part of the interprofessional team.

Target Audience

This activity has been designed to meet the educational needs of individuals in nursing.

Learning Objectives

At the conclusion of this activity, the learner will be better able to:

  • Identify the mechanism of action of warfarin.
  • Review the agents that can either increase or decrease the anticoagulant effect of warfarin.
  • Summarize the target INR levels for warfarin therapy based on conditions that affect INR targets.
  • Describe the importance of collaboration and coordination among the interprofessional team and how it can enhance patient care with warfarin therapy in conjunction with the patient's entire medication regimen to improve patient outcomes for patients with conditions where anticoagulation is indicated.


StatPearls requires everyone who influences the content of an educational activity to disclose relevant financial relationships with ineligible companies that have occurred within the past 24 months. All relevant conflict(s) of interest have been mitigated. Hover over contributor names for financial disclosures. None of the planners of this educational activity have any relevant financial relationships to disclose.

COMMERCIAL SUPPORT: This activity has received NO commercial support.


Continuing Education Accreditation Information

Credit provided by Continuing Education, Inc, and StatPearls, LLC.

In support of improving patient care, this activity has been jointly planned and implemented by Continuing Education, Inc./University at Sea® and StatPearls, LLC. Continuing Education, Inc, is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

This activity is designated for 1.50 ANCC contact hours.


Instructions for Credit

  1. Register for the activity and create a StatPearls login.     
  2. Review the target audience, learning objectives, and disclosure information.
  3. Study the educational content in the activity.
  4. Choose the best answer to each activity test question. To receive credit, you must pass the test questions with a minimum score of 100%.
  5. Complete the post-activity assessment.
  6. Obtain a certificate.

For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.


Faculty may discuss investigational products or off-label uses of products regulated by the US Food and Drug Administration. Readers should verify all information before employing any therapies described in this educational activity.

The information provided for this activity is for continuing education purposes only and is not meant to substitute for the independent medical/clinical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. The information presented does not necessarily reflect the views of StatPearls or any commercial supporters of educational activities on statpearls.com. StatPearls specifically disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through a participant's misunderstanding of the content.

Cancellation Policy: Cancellations must be received in writing and a money-back guarantee is provided if not completely satisfied.

  • StatPearlsand and Continuing Education, Inc, reserve the right to cancel any course due to unforeseen circumstances. StatPearls and Continuing Education, Inc, will not be responsible for other expenses incurred by the participant in the unlikely event that the program is canceled.

Medium or Media Used:

  • Computer Requirements: Internet Access
  • E-mail Address

Equal Opportunity

  • StatPearls and Continuing Education are Equal Opportunity/Affirmative Action/Equal Access Institutions. 


Media Usage Rights

The contributors and editors of StatPearls have attested that all associated media (images and video) have been legally cleared for use with this activity.  All copyrights are reserved.


    Valentine C. on 4/14/2021

    Edward I. on 7/31/2021

    Barbara C. on 8/17/2021

    Peggy K. on 9/14/2021

    marshall s. on 12/4/2021

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    Kenneth R. on 12/10/2022

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    Deborah V. on 1/8/2023

    Lisa B. on 1/30/2023

    Christine G. on 3/14/2023

    Amy A. on 4/7/2023

    Nicole S. on 5/3/2023

    Expand this course to include more drugs and icrease CEUs to 3.

    JAMI W. on 5/27/2023

    would be helpful to have a more comprehensive list/table of drug interactions w/warfarin.

    Angela D. on 6/6/2023

    Leah S. on 6/12/2023

    VLADIMIR E. on 6/29/2023

    Terry P. on 8/19/2023

    Rey V. on 8/17/2023

    Van J. on 8/22/2023

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