Anatomy, Airway

Structure and Function

Airways allow airflow in ventilation from the external environment to the respiratory surfaces where gas exchange for respiratory processes can occur.[4][5]

To allow this and to maintain homeostasis and adequate protection from the external environment they must also perform other barrier functions.

• Moisture barrier is the mucous lining of the airway that provides a barrier to prevent loss of excessive moisture during ventilation by increasing the humidity of the air in the upper airway
• Temperature barrier is relative to body temperature as the external environment is nearly always colder, and the increased vasculature and structures such as nasal turbinates warm air as it enters the airways
• A barrier to infection as the airways are lined with a rich lymphatic system including mucosa-associated lymphoid tissue (MALT) that prevents early access to any invading pathogens. Macrophages also patrol the respiratory surfaces providing an important component of the “air-blood barrier."

Embryology

The upper airways develop from the pharyngeal arches as part of the embryological development of the head and neck structures.

At around four weeks, the larynx and lower airways develop from the longitudinal laryngotracheal groove which forms a medial, groove-like structure becoming a tubular, blind-ended structure called the laryngotracheal diverticulum. This eventually separates from the developing foregut by the formation of the tracheo-oesophageal folds.

The laryngeal cartilages and musculature develop from the four and six pharyngeal arches, and the glottic opening forms connecting this region to the trachea.

The trachea forms from the extension of the laryngotracheal diverticulum, and it is lined with endodermal tissue which forms the specialized respiratory linings and mesodermal structures that form the cartilage and smooth muscle walls.

As development continues, the laryngotracheal diverticulum continues to branch and bud and forms the bronchi and branching bronchioles.

From 16 weeks onward, respiratory surfaces begin to form, and the maturation of the lungs develops with alveolar sacs forming and pneumocyte development forming the respiratory membrane.

The formation of the alveoli and the respiratory membrane is not complete until after birth, and alveolar formation continues until the age of eight.

Blood Supply and Lymphatics

The upper airways receive blood supply from various branches of the external carotid artery and drain into the internal jugular. The naso and oropharynx also receive blood supply from the facial artery branch of the external carotid via the tonsillar artery. The venous drainage of these structures is via the pharyngeal plexus into the internal jugular vein. The lymphatic drainage is through various lymphatic plexuses of the neck surrounding the internal jugular vessels.

The lower airways receive blood flow from two sources: the pulmonary circulation and the bronchial circulation.

The pulmonary circulation provides blood from the heart for oxygenation through the right and left pulmonary arteries which follow a branching structure similar to that of the airways themselves. This blood returns as oxygenated blood through the pulmonary veins which follow an independently branching structure to return to the right ventricle.

Bronchial circulation provides oxygenated blood to the airway structures themselves. These arteries arise independently from the systemic circulation. The two left bronchial arteries emerge from the thoracic aorta; whereas, the right bronchial artery arises either from one of the superior posterior intercostal arteries or a common trunk with the left superior bronchial artery. These provide nutrition and oxygen to tissues as far as the end of the conducting airways where they anastomose with the pulmonary circulation.

The bronchial veins are only present near the lung hilum which drain blood from the trachea, and bronchi drain into the azygos vein on the right and either the accessory hemiazygos veins or the intercostal vessels on the left. Pulmonary veins drain the more distal circulation where a small amount of deoxygenated blood makes a minimal impact on the saturation of the returning blood.

Lymphatic drainage of the lower airways is through the deep lymphatic plexuses of the pulmonary lymphatic plexuses. These drain to the superior and inferior tracheobronchial lymph nodes bilaterally and then to the right and left ducts connecting to the venous angles, usually directly but on the left, this may converge with the thoracic duct first.

Paratracheal nodes drain lymph from the trachea directly into the right and left lymphatic ducts.

Nerves

Innervation of the pharynx is via cranial nerves VII, IX, X, and XII. The larynx is supplied by the vagus (cranial nerve X) by the superior laryngeal branch directly and the clinically important recurrent laryngeal branch.

The lower airways receive parasympathetic fibers from the vagus, some of which are afferent sensory nerves that transmit cough sensations from specialized J receptors in the mucosa as well as stretch receptors from the bronchial muscles and inter-alveolar connective tissues. The efferent fibers of the vagus cause broncho-constriction and secretion from the glandular tissues in the airways. The efferent sympathetic fibers cause bronchodilation by inhibiting the activity of the smooth muscles of the airways.

Muscles

The muscles of the pharynx and larynx provide the structure of the upper airways and form from striated muscles under visceral and somatic control. They relate to the action of swallowing.

The lower airways have a layer of smooth muscle within their walls. It is present along all of the conducting airways and allows for visceral control of bronchoconstriction

Physiologic Variants

The most common anatomic variation is an abnormal tracheo-oesophageal fistula. This variation occurs most commonly in males and often is associated with oesophageal atresia. It occurs with the incomplete fusion of the tracheo-oesophageal folds which would divide the developing foregut into respiratory and oesophageal portions.

Surgical Considerations

The anatomy of the airway is important in all trauma and emergency surgical scenarios. As in any emergency assessment, a practitioner should know it is most important to consider and evaluate the patent airway.[6][7][4][8]

The upper airways can be controlled using airway devices and bypassed using endotracheal intubation. If this is not possible, emergent surgical access to the airway is imperative and is performed through an emergency cricothyroidotomy.

Airway assessment is relevant to many common surgeries:

• Tonsils causing any airway compromise indicate surgical removal.
• Any neck trauma external to the airway can cause an external compression which can compromise the airway. This compromise is of particular importance in trauma and operations on surrounding structures such as thyroidectomy.

Clinical Significance

The importance of the upper airway assessment is paramount in both emergency and anesthetic scenarios.[9]

The upper airway assessment can be performed and enhanced by the following assessment tools:

• The Malampati score which describes the visible airway
• The "3, 3, 2" rule in which three estimated measurements of the inter incisor distance
• The hyoid-mental distance, hyoid-thyroid cartilage distance is measured, and if these are shortened, it implies a difficult airway.

The cricoid cartilage is important both as a clinical landmark and also as the only complete cartilage ring within the upper airway used during cricoid pressure maneuvers.

The narrowest portion of the upper airway is the cricoid cartilage in children; therefore, cricothyroidotomy is not recommended in children younger than the age of eight. As children grow and mature, the glottic opening becomes the most narrow point in the airway, and therefore, the most likely point of obstruction and allows bypass by the insertion of a cricothyroidotomy airway.

The trachea is the most anterior structure of the neck except for where the thyroid covers it. This means that it can be accessed to provide an airway in both emergencies (cricothyroidotomy) and elective procedures (tracheotomy).

The trachea should align with the sternal notch. If this alignment deviates, it can indicate a lung or mediastinal pathology.

The right, main bronchus is shorter, wider, and vertically aligned, and this means it is the most common site for aspiration, both in a foreign body aspiration and during the occurrence of an aspiration pneumonitis causing right lower lobe consolidation.

In clinical assessment of the lower airways, through auscultation and by the presence of "wheezing" as turbulent airflow generates a musical noise, airway narrowing through edema or bronchoconstriction can be detected.