Cardiac Dominance

Issues of Concern

As with any coronary artery, the posterior descending artery is subject to possible stenosis or occlusion secondary to atheromatous plaque accumulation or thrombosis. The result of stenosis to the posterior descending artery would be decreased perfusion or even infarction of the posterior third of the interventricular septum, depending on the severity. Therefore, the location of the possible infarction or reduced perfusion depends on the individual's cardiac dominance. For example, a patient who is left-heart dominant and suffering from severe stenosis of the proximal left main coronary artery may suffer infarction of the posterior interventricular septum. However, this would not be true in a patient with codominant coronary circulation. A stenotic lesion to the proximal left main coronary artery would decrease perfusion to the posterior interventricular septum. However, it would still receive blood via the right coronary artery, reducing the risk of an infarct.

In right-dominant coronary circulation, the posterior descending artery is a collateral vessel to the basal left anterior descending artery through septal perforators.[6] This would mean that a patient with proximal left anterior descending coronary artery stenosis has the additional benefit of possibly receiving supply from the right coronary artery if he or she is right-heart dominant. This collateral circulation may be enough to bypass the blockage in the left anterior descending artery to provide enough oxygenated blood to allow the cardiac muscle to survive and recover.

Clinical Significance

Cardiac dominance is essential in cardiac surgery, particularly coronary artery bypass grafting. Cardiac dominance is determined through cardiac catheterization, which involves the insertion of a catheter into the ostium of the left main coronary artery and the right coronary artery and the injection of radiocontrast dye to allow visualization of coronary arteries.  In coronary artery bypass grafting procedures, precise knowledge of patient-specific coronary anatomy is crucial because the surgeon must identify which vessels are suitable to receive the distal anastomosis of the venous graft. The posterior descending artery may be suitable for occlusion of the right or left coronary artery, depending on its patency. The venous conduit is then sutured into a portion of the right coronary artery distal to the occlusion.   

Many studies have been conducted to determine the significance of cardiac dominance on patient outcomes and pathology. One study revealed that patients with left coronary dominance have a reduced prognosis in surgical myocardial revascularization. The exact reason remains undetermined, but speculation is that there is an association with collateral circulation seen in right heart-dominant patients that is absent in left heart-dominant subjects.[7]

Left-heart dominance was described to be a high-risk feature for percutaneous coronary intervention as well. Left-heart–dominant patients undergoing percutaneous coronary intervention have higher in-hospital mortality and are more likely to present with symptoms of heart failure, cardiogenic shock, or cardiac arrest.[8] Left-heart dominance in patients undergoing aortic valve replacement for severe aortic stenosis was also shown to be an independent risk factor. There appears to be an increased prevalence of left-heart dominance in patients undergoing aortic valve replacement, and the left main coronary artery is significantly shorter than those seen in right-heart–dominant patients; this may be evidence of a developmental relationship seen in left-heart–dominant patients between the left main coronary artery and aortic valve. In one study, patients with left dominant coronary circulation were determined to suffer a significantly higher rate of perioperative myocardial infarction compared to right heart dominant or codominant patients.[9]

These studies and trials highlight the significance of determining dominance in coronary artery anatomy in treating cardiac pathology. The increased risk seems to correlate with left- heart–dominant circulation. Still, more research must be done to determine if different strategies must be implemented to ensure better outcomes.