Epididymitis

Etiology

The majority of cases of epididymitis occur as a result of bacterial infection. The types of bacterial infection include common urinary pathogens as well as pathogens known to cause sexually transmitted disease. In most cases of epididymitis, infection occurs either as a result of the retrograde flow of urine, most commonly seen in elderly males, or as a result of a sexually transmitted disease, most often encountered in males ages 20 to 40. In males prior to sexual maturity, the most common cause of epididymitis is inflammation that occurs as a result of trauma or repetitive activities such as sports. The possibility of a sexually transmitted disease, however, must be considered even in males prior to sexual maturity due to the possibility of sexual abuse. Other possible causes of epididymitis include chemical, drug-induced, and viral infections.[4][2][5]

Epidemiology

Epididymitis can occur in men of any age, though the majority of cases of epididymitis occurs in males ages 20 to 39 and are most often associated with a sexually transmitted disease. Chlamydia trachomatis and Neisseria gonorrhea account for approximately 50% of cases of epididymitis associated with chlamydia and gonorrhea in males less than 39 years of age. After 39 years of age, the most common etiologic agent responsible for epididymitis is Escherichia coli and other coliform bacteria found in the gastrointestinal tract. In males prior to sexual maturity, epididymitis may still be caused by bacterial infections, but it is more common that epididymitis occurs as a result of an inflammatory process, such as repetitive activities like sports (e.g., running, jumping). Though rare, chemical epididymitis may occur as a result of exercising or having sexual intercourse with a full bladder, resulting in a retrograde flow of urine. Also, epididymitis may occur as a result of certain medications, namely amiodarone used in the treatment of cardiac dysrhythmia. Lastly, viral infections, such as mumps virus, can result in epididymitis or epididymo-orchitis.

Epididymitis is the most common cause of acute scrotal pain in adults. More than 600,000 men are affected yearly in the United States.

Pathophysiology

Epididymitis most often occurs as a result of a bacterial infection. In the case of a sexually transmitted disease, bacteria are introduced during sexual intercourse and migrate through the genitourinary tract to the epididymis. In cases of infection due to urinary tract infection, retrograde flow of urine or stagnation of urine along the genitourinary tract results in infection of the epididymis. When epididymitis is caused by repetitive movements, the mobility of the scrotum and its contents can result in inflammation of the testes or the epididymis. Certain viruses, namely mumps virus, have a predisposition to infect the testis.

History and Physical

The patient will likely complain of scrotal pain and swelling, quite often gradual in onset rather than acute. It may begin with flank pain that migrates to the scrotum. The patient may also complain of urinary symptoms such as dysuria, urinary frequency, urgency, or incontinence of urine. The patient might also complain of urethral discharge. A careful history should include the possibility of traumatic injury or injury from repetitive activities such as sports, sexual history including history of prior sexually transmitted disease exposures, and past medical history including problems associated with the genitourinary tract such as prior urinary tract infection, prostatitis, or surgical procedures.

A physical exam will likely reveal swelling of the scrotum, and palpation of the scrotum will likely reveal tenderness of the scrotum, usually unilaterally but in some cases bilaterally. Tenderness to palpation of the epididymis along the posterior and superior aspect of the testis is the hallmark of epididymitis. Tenderness upon palpation of the testis itself may indicate the possibility of epididymo-orchitis or orchitis. The skin overlying the scrotum may appear warm, erythematous, inflamed, and indurated as a result of infection. Tender inguinal adenopathy may be present as well. Physical examination of the penis may demonstrate a urethral discharge. Digital rectal examination may demonstrate tenderness upon palpation of the prostate gland. These findings, while not necessarily indicative of epididymitis itself, might be present in infections of the male genitourinary tract.

Evaluation

Evaluation of the male patient with scrotal pain should begin with urinalysis. Though nonspecific, the presence of red blood cells and white blood cells in the urine may indicate an acute infectious or inflammatory condition. Urine should be cultured to determine the causative agent in cases associated with urinary tract infection. A urethral swab is indicated in cases where the sexually transmitted disease is considered likely given the patient's sexual history. The radiographic evaluation includes ultrasonography with attention not only to the anatomic structure but also to assess vascular flow to the testis. Ultrasonography can demonstrate inflammation of the epididymis and testis in cases of epididymitis and epididymo-orchitis. Computerized tomography also may be of use in cases where the patient has flank pain and urinary symptoms associated with an acute genitourinary problem such as ureterolithiasis.[6][7][8]

Of utmost importance is ruling out the possibility of testicular torsion as a cause of scrotal pain. While epididymitis tends to occur rather gradually, the pain associated with testicular torsion often occurs very abruptly. History alone, however, may not be sufficiently clear to exclude the possibility of testicular torsion as a result of acute scrotal pain without the aid of emergent urological consultation and ultrasonography.[9]

Treatment / Management

Treatment of epididymitis is based upon identification of the causative organism, though presumptive treatment may be initiated based upon the prevalence of the most typical agents (C. trachomatis, N. gonorrhea, E. coli). For suspected sexually transmitted cases, ceftriaxone along with doxycycline is recommended although azithromycin can be used as an alternative. Fluoroquinolones may be used in older patients where an enteric organism is suspected or likely. Pain and swelling can be dramatically reduced in many cases by using ice.[10][11][12]

Epididymitis caused by repetitive activity is treated symptomatically with rest, anti-inflammatory medications, scrotal support, and close primary care follow-up.

Differential Diagnosis

The differential diagnoses of epididymitis include but are not limited to the following:

• Epididymal congestion following vasectomy
• Hydrocele
• Orchitis
• Referred or radicular pain
• Scrotal trauma
• Spermatocele
• Testicular trauma
• Testicular seminoma
• Tunica vaginalis tumor
• Urinary tract infection

Prognosis

Older age, previous history of diabetes mellitus, fever, higher white blood cell count, C-reactive protein level, and blood urea nitrogen level are independently associated with severity of epididymitis.[13] Patients with epididymitis secondary to a sexually transmitted disease have 2-5 times the risk of acquiring and transmitting HIV.[14] The outcomes for most men with epididymitis are excellent, but relapses may occur in patients who are not compliant with therapy.[15]

Complications

Epididymitis if not treated properly or promptly can lead to the following complications:

• Infection of the epididymis can lead to the formation of an epididymal abscess
• Progression of the infection can lead to the involvement of the testicle, causing epididymo-orchitis or a testicular abscess
• Sepsis is a potential consequence of severe infection
• Bilateral epididymitis may result in sterility due to occlusion of the ductules from peritubular fibrosis