Extubation

Indications

All patients who are on mechanical ventilation for any reason require liberation as soon as possible. Clinicians should consider the cause of the patient's respiratory failure, prognosis, expected course of the disease, and the absence of any reasons to stay on mechanical ventilation for a longer time.

Providers should start planning extubation as early as day one of intubation.

Any patient who successfully passes the spontaneous breathing trial (SBT) should be extubated unless there is a change in management plans. 

Contraindications

Extubation is contraindicated in patients who are not candidates for initiating ventilator liberation strategy and in those who have failed the spontaneous breathing trial.

Generally, the following groups of patients are not candidates for liberation; however, individual cases vary.

1. Acute respiratory failure needing active management: The cause of respiratory failure should be resolved or significantly improved even to consider placing patients on liberation pathways.
• Any patient with a PaO2/FiO2 ratio less than 150, needing FiO2 over 0.40 or PEEP greater than 10, minute ventilation requirement greater than 15 L per minute, rapid shallow breathing index over 105 (shallow rapid breaths with higher respiratory rate and lower tidal volumes), excessive secretions, worsening chest imaging, are not ready for considering extubation.
• Patients should be able to maintain adequate oxygenation and ventilation with low-level respiratory support, which patients can manage spontaneously or be provided with non-invasive modalities.
2. The patient should be able to protect the airway, maintain airway patency, have a strong cough, and have minimal secretions. 
3. The four most important things to remember are mental status, oxygenation, ventilation, and expectoration (acronym, MOVE).
4. Any cardiovascular instability is a contraindication:
• Tachycardia (higher than 140) of any sort needs active management.
• Shock state of any etiology requiring higher doses of vasopressor support - patients can be safely extubated sometimes if they are on small doses of one vasopressor and no other contraindication.
• The patient should not have any active ischemia or pulmonary edema.
5. A Glasgow coma scale (GCS) of less than 8 is a contraindication. In rare situations, patients with low GCS can be extubated if they have a good gag and cough and the absence of any other contraindications.
• For most patients considered for extubation, mental status should be alert, awake, and able to follow commands. There should be no other neurologic abnormality impairing the patient's ability to breathe spontaneously.
6. Any acute brain injury (including an invasive intracranial pressure measuring device for raised intracranial pressure) where such an injury was the primary reason for intubation.
7. Plans to return to the operating room needing general anesthesia in the next 24 hours. Extubation should not be attempted as the patient will be re-intubated for surgery and may remain on the ventilator for a few more days, depending on the outcomes of the surgery.
8. Current use of paralytic agents for any reason.
9. The presence of an open abdomen is generally a contraindication - if the patient is subject to rigorous SBT, it can jeopardize surgical management.
10. Ongoing therapeutic hypothermia is also a contraindication.

Equipment

All equipment needed for intubation should be readily available, including two to three different sizes of ETTs, bag-mask with positive end expiratory-pressure (PEEP) valve, airway bougies, tube exchangers, traditional direct laryngoscope, video laryngoscope, flexible bronchoscope, drugs needed for induction, and suction catheters.

Ideally, an airway bag should be available in all ICUs. It should include supraglottic airways, video laryngoscopes, and cricothyrotomy kits.

Equipment for oxygenation post-extubation should be available, either a nasal cannula, oxygen mask, venturi mask, high-flow oxygen system, or continuous positive airway pressure (CPAP)/bilevel positive airway pressure (BPAP).

Personnel

A respiratory therapist and bedside nurse should be present with the intensivist for extubation in the ICU. A clinician skilled in airway management should be available in the operating room. An anesthesiologist should be available during the extubation of a difficult airway in either location.

Preparation

The preparation for extubation is a long process, which begins on the day of the patient's intubation and continues through the acute management of the primary problem which caused respiratory failure.

All ventilated ICU patients should be assessed daily for readiness to wean. Physicians should determine the benefits of early weaning versus morbidity and mortality associated with failed extubation. A weaning/liberation protocol should be in place to achieve this goal (see Image. Safe Extubation Checklist). It should have the following components:

1. The first step involves screening for any exclusion from initiating the liberation pathway. Please refer to the contraindications section to review all those criteria. 
2. The patient should be evaluated and screened with weaning parameters if there are no exclusions.
3. If deemed a good candidate, the patient should start the SBT.
4. During the SBT and at the end of the SBT, assess for failure/pass of the SBT.
5. If the patient passes the SBT, proceed with extubation without delay.

During the preparation phase of extubation, practitioners should pay attention to the following:

1. Nocturnal rest with full ventilatory support before the morning of the trial.
2. Ensure adequate nutrition.
3. Avoid excessive intravascular volume and consider diuresis if not contraindicated.
4. Treat any infections and avoid fever, as it may increase the ventilatory requirement.
5. Ensure appropriate body position with head up and propped up if possible.
6. Avoid obstipation, urinary retention, gastric distension, musculoskeletal pain, and severe anemia.
7. If significant pleural effusion is present, consider tapping before extubation.
8. Avoid chemical imbalances.
9. Manage secretions aggressively before the SBT and even consider bronchoscopy to inspect airways to clean out inspissated secretions if appropriate. 

Assessment of Readiness to Wean

The assessment considers all the contraindications above, including clinical improvement of the cause of respiratory failure, oxygenation and ventilation parameters, mental status, secretions, cardiovascular stability, and specific weaning parameters.

Weaning Parameters

Several weaning parameters have undergone assessment and use in clinical studies, which are helpful when taken into account with the overall clinical picture, but they are not very sensitive or specific when considered individually.[3][4]

• Minute ventilation (tidal volume x respiratory rate) of less than 10 L per minute only correlates with a positive predictive value of 50% and a negative predictive value of 40%.
• Maximum negative inspiratory pressure of greater than 30 cm of water is considered a measure of inspiratory muscle strength and a good predictor of weaning success, but this finding has not been replicated in studies.
• Static compliance (tidal volume/plateau pressure minus PEEP) has low negative and positive predictive values in the range of 50 to 60%.
• Occlusion pressure (P 0.1), which is the pressure at 0.1 seconds after initiation of a spontaneous breath, has shown conflicting results in studies.
• Reduction of venous oxygenation saturation (ScvO2 over 4.5%) after 30 minutes of the SBT in patients who failed their first T-tube SBT is an independent predictor of reintubation with a sensitivity of 88% and specificity of 95%.
• Rapid shallow breathing index (RSBI; respiratory rate / tidal volume) measured over one minute in a spontaneously breathing patient on low-level PEEP only has higher sensitivity of 97% and moderate specificity of 65% for predicting patients who will subsequently pass the SBT.[5]
• The most common weaning parameters to consider initiating the SBT are RSBI of less than 105, maximal inspiratory pressure (MIP) of less than -30 cm of water, and minute ventilation of lesser than 10 liters per minute.

Spontaneous Breathing Trial (SBT)

Initiation of the weaning trial commences at the time of the first spontaneous breathing trial. The duration of the SBT can be between 30 minutes and 2 hours.[6][7] Several techniques can be used to conduct the SBT:

• T-tube (T-piece) trial
• Pressure support ventilation
• Automatic tube compensation
• Continuous positive airway pressure
• Automated weaning

Several studies have evaluated pressure support ventilation, automated tube compensation, CPAP, and T-piece trial and noted that none is superior to the other.[8][9][10]

T-tube Trial

This approach is a well-established method. It involves attaching the end of the ETT to a short piece of tubing that acts as a reservoir and provides a connection to humidified fresh gas flow. This method is simple, well tested, and imposes a pulmonary workload comparable to that encountered after extubation; this is labor-intensive, and there is no monitoring of flow, pressure, or volume, and there are no alarms. A similar method called "flow by" can also be used when ventilating pressures, rate, and tidal volume are set to zero while the patient is still attached to the ventilator. 

Pressure Support Ventilation

It is becoming a more widespread technique for conducting the SBT. Despite theoretical concern that pressure support ventilation may not mimic the true post-extubation workload and difficulty predicting the level of support necessary to compensate for resistive load completely, this does not appear problematic in practice. 

Automatic Tube Compensation

In this method, the ventilator compensates for the degree of resistance provided by the ETT. It is available on most modern ventilators.

Continuous Positive Airway Pressure (CPAP)

CPAP is said to increase functional residual capacity and maintain small airways. It is also beneficial for left ventricular dysfunction and has minimal side effects. Despite the potential risk that a patient may pass the SBT but experience cardiac failure on extubation, most clinicians are comfortable using low CPAP levels with other techniques mentioned earlier.

Automated Weaning

Automated weaning aims to reduce the requirement for clinician input in a weaning process and improve outcomes. These automated systems use closed-loop controls to interpret clinical data in real time, gradually reduce pressure support, and perform the SBT. At least three different clinical trials and one meta-analysis have shown that the weaning time can be reduced with a computer-driven automated weaning protocol.[11][12][13][14][15][16]

Suitability for Extubation

If the patient has passed the SBT, they should undergo reassessment for the suitability of extubation. Many of these assessments may have been done at the start of the weaning trial or as a part of the daily assessment of the patient's readiness to wean.

The most important part of this assessment is assessing the ability of the patient to protect and maintain a patent airway.

• The patient should have an adequate level of consciousness - a GCS greater than 8 suggests a higher likelihood of successful extubation.
• The patient should have a strong cough:
  • Most clinicians objectively determine the presence of a moderate to strong cough before extubation, although there are other objective measures like card moistening and spirometry testing for maximal expiratory pressure (MEP).
  • The presence of a weak cough, measured as a cough peak flow of 60 L/min or less, is a strong independent risk factor for extubation failure.
• The patient should be assessed for the volume and thickness of respiratory secretions.
• The most common test for airway patency is the cuff-leak test which is neither sensitive nor specific. 
• Providers need to ensure that they know the airway anatomy noted at the time of intubation, potentially difficult airway, and techniques used to intubate the patient - in the case of the known difficult airway, ensure to have all equipment available for difficult airway. If extra personnel is needed, they should be informed beforehand and be available at very short notice.

Technique or Treatment

• After a successful weaning trial/SBT, a decision is made to proceed with extubation.
• All necessary equipment should be available for extubation management, and the rest of the equipment should be available nearby in case extubation does not go as planned.
• The patient should be in an upright sitting position.
• Both the ETT and oral cavity are suctioned - if there is a subglottic suction, it should be utilized to remove all secretions above the ETT cuff. If no subglottic suction is available, use a small-bore catheter to insert on the side of the ETT and suction all secretions above the ETT cuff.
• The ETT is removed from the holder; when ready to be removed, ask the patient to take a deep breath and exhale. During exhalation, deflate the cuff and smoothly take out the ETT.
• If an orogastric tube is present, it is also removed alongside the ETT. This decision should be made before extubation, considering the need for oral medications and nutrition. Some patients may not be ready for oral intake and require a nasogastric tube placement upon removal of the orogastric tube. 
• After removing the ETT, suction the oral cavity and ask the patient to take a deep breath and cough out all secretions.
• The patient should be placed on supplemental oxygen afterward.
• The patient should be observed very carefully over the next few hours.
• Frequent airway suction should be considered to prevent re-intubation.
• The timing of extubation (day, evening, night) depends on the institution and individual ICU, but the most critical factor to consider is the availability of adequately experienced personnel.

Strategies for Smooth Extubation and Smooth Emergence

• Deep extubation
• Endotracheal tube exchange to Laryngeal Mask Airway (LMA)
• A “no-touch” extubation technique
• Pre-oxygenation with 100% Fraction of Inspired Oxygen (FiO2)
• Bite Blocks
• Pharmacotherapy- IV or intracuff lidocaine, IV remifentanil, and dexmedetomidine.[17]

Grades of Recommendations Advocated During the Process of Extubation

Post-Extubation Management

The immediate post-extubation phase should be managed as carefully as the ventilated phase because the first 24 hours post-extubation are difficult and tenuous.

1. Ensure adequate oxygenation: Consider nasal cannula, oxygen mask, full face mask, and venturi mask as appropriate to ensure good O2 supply.
2. In recent times, high-flow oxygen systems have gained popularity in selected patients with hypoxemic respiratory failure, and studies have shown to reduce the re-intubation rate.
3. If needed, consider CPAP/BPAP for selected high-risk patients to avoid re-intubation.
4. Ensure adequate secretion management, encourage coughing and deep breathing, and maintain airway hydration and the patient's central airway.
5. Use adequate bronchodilators as needed. 
6. Encourage sitting up position and mobility if no other contraindications exist.
7. Carefully introduce oral feeding. In at-risk patients, continue enteral feeding with a nasogastric tube until the patient is deemed safe to swallow and tolerate food orally.

Complications

Adverse events relating to the procedure can be dichotomized into three categories:

1. Respiratory - Exaggerated laryngeal reflexes causing coughing, bucking, or laryngospasm - aspiration, secondary to residual effects of drugs and inadequate relaxation, is the major cause of mortality as well as malpractice claims due to anesthesia-related adverse events. 
2. Traumatic - Injury to the larynx, vocal cords, laryngeal nerves, dental trauma, lingual trauma, and emotional distress.
3. Hemodynamic – Post-extubation hemodynamic shift and increased intra-thoracic pressure following vigorous coughing.[17]

The most feared complications of extubation are the failure and immediate need for re-intubation and post-extubation stridor.

Extubation Failure

Extubation failure and the need to be re-intubated within 48 hours are noted in 10 to 20% of patients despite passing a spontaneous breathing trial and undergoing planned extubation.[18] 12 to 14% of planned extubations. Extubation failure increases the length of mandatory ventilation, odds of the need for tracheostomy, medical expenditure, and the risk of mortality.[18][19] Risk factors for reintubation include a weak cough and frequent suctioning. Additional features that may predict reintubation include a rapid shallow breathing index over 58 breaths per minute per liter, a positive fluid balance during the 24 hours preceding extubation, and pneumonia as the reason for the initial intubation. Patients aged 65 and older with severe chronic cardiac or respiratory disease appear to be at particularly high risk for extubation failure. Extubation failure carries a higher risk of ICU mortality.[20][21]. 

Recently, the use of non-invasive ventilation (NIV), mostly in the form of BPAP, has gained prominence. Current evidence favors prophylactic use of NIV immediately after extubation to prevent reintubation in only selected high-risk patients, like chronic obstructive pulmonary disease (COPD) and hypercapnia. Otherwise, NIV use for post-extubation respiratory failure has not been shown to reduce reintubation rate or ICU mortality.[22][23]

In addition to using NIV, high-flow oxygen systems have gained popularity over the last few years in selected patients with hypoxemic respiratory failure. Studies have shown to reduce the re-intubation rate.[24][25][26][27][28][29]

Various Clinical Parameters to Predict the Outcome Following Extubation 

Glasgow coma scale-Glasgow Coma Scale (GCS) before extubation has been observed to be the most significant variable governing the outcome following extubation.[18][30][31]

1. Cough strength, level and consistency of secretion, and status of gag reflex[31]
2. Indexes such as heart rate, acidosis, consciousness, oxygenation, and respiratory rate (HACOR)[32]
3. Point of care holistic ultrasound- to assess left ventricular function), number of B-lines, and diaphragm thickening fraction - diaphragmatic excursion (DE) with a cut-off value of 1.25 cm and diaphragmatic thickening fraction (DTF) with a cut-off value of 21.5% indexes during the diaphragmatic US have high positive predictive values[33][34][35][36]
4. Synchronization between the thoracic and the abdominal wall movement[36]
5. Changes in ΔPCO2 (Δ - ΔPCO2) and central venous oxygen saturation (ΔScvO2) during spontaneous breathing trials[36]

Weaning Failure

Weaning failure means that the patient cannot tolerate the SBT, which is different from extubation failure, where the patient can pass the spontaneous breathing trial leading to successful extubation, which later fails. An international consensus conference proposed a classification of patients based on the difficulty and length of the weaning process.[1] Accordingly, patients are categorized into three groups: simple, difficult, and prolonged weaning.[1] The simple weaning group (30 to 58% of patients) is easy to wean and able to be extubated after the first SBT. The difficult weaning group (26 to 40% of patients) requires up to 3 SBTs or up to 7 days to achieve successful weaning. Both of these groups have relatively lower mortality of 0 to 13%. The prolonged weaning group (6 to 30% of patients) requires more than 3 SBTs or more than seven days to achieve successful weaning. The third group has higher mortality of 13 to 22%. Any weaning failure should prompt physicians to comprehensively assess the patient for all potential problems which can cause weaning failure. Subsequent SBT should only occur when these presumed predisposing factors have been addressed.[37][38]

Unexpected Extubation

A systematic review and meta-analysis have shown the pooled prevalence of UEE at around 7%, with almost 70% occurring despite being preventable.[39] Preventive measures such as restraint and proper fixation of the tracheal tube are paramount to preventing such adverse events.[39]

Post-Extubation Stridor

Post-extubation stridor is uncommon and seen only in less than 10% of unselected critically ill patients and correlates with increased rates of reintubation, prolonged duration of mechanical ventilation, and longer length of ICU stay. Stridor is the result of laryngeal edema.

Several identified risk factors include:

• Prolonged intubation (36 hours to 6 days or more)
• Elderly: above 80 years of age
• A large ETT (greater than 8 mm in men and over 7 mm in women)
• A ratio of ETT to the laryngeal diameter of more than 45%
• A GCS score higher than 8 or traumatic intubation
• Female gender
• Medical history of asthma
• Improper fixation of the tube
• Inadequate or lack of sedation
• Aspiration
• The presence of an orogastric or nasogastric tube

The cuff-leak test is used to predict the occurrence of post-extubation stridor.[40] It should be performed if any of the risks mentioned above are identified. Some providers do the cuff-leak test regularly, but there is insufficient evidence to suggest its regular use.

The two methods of performing the cuff-leak test are:

• Qualitatively by just listening to the leak of air by a stethoscope over the upper trachea on deflation of the balloon.
• Quantitatively, placing the patient on volume control mode and calculating the difference between inspired and expired air. If the cuff leak is less than 110 ml or less than 25% of the delivered tidal volume, it suggests an increased risk of laryngeal edema.

Management of Post-extubation Stridor

For patients with no cuff leak when tested before extubation, a short course of steroids (methylprednisolone 20 mg every 4 hours for four doses) may be helpful. This course has support from a few studies and meta-analyses.[41][42]

For patients who develop post-extubation stridor, nebulized epinephrine, intravenous methylprednisolone, high flow O2, and CPAP is an option if clinically stable. Otherwise, prompt reintubation is warranted if significant airway obstruction is suspected. Following reintubation, a short course of steroids is the recommendation, with a re-assessment of the cuff leak. If a leak is present, extubation is generally safe. If cuff leak is reduced or absent, extubation over an airway exchange catheter should be considered, usually in consultation with bedside anesthesiology or ENT consultant.[43]

Clinical Significance

Intubation and extubation are both critical aspects of the hospital management course for any critically ill patient and require documentation in electronic medical records with dates and times along with the complications and difficulties encountered.

Enhancing Healthcare Team Outcomes

The ventilator liberation process is long and involves many factors that require the attention of multiple members of the patient interprofessional care team. This team includes clinicians, nursing, and respiratory technicians. Coordination between different providers is essential.

The SBT cannot be conducted without first conducting a spontaneous awakening trial.[44][45] This trial requires close coordination between the bedside nurse and the bedside respiratory therapist. As a part of the daily morning assessments, "sedation vacation" should be included to the point that the patient is alert, awake, and able to follow commands.[46] While the nurse is doing daily sedation vacations or spontaneous awakening trials, the respiratory therapist assesses readiness to wean and initiate the spontaneous breathing trial.

Communication between all team members is crucial so everyone knows their roles and responsibilities. A team-centered, interprofessional approach to care during extubation that includes physicians, nursing, respiratory therapists, and pharmacists is the best approach to achieving a positive patient outcome, irrespective of the events during extubation.

Several studies have demonstrated a significant reduction in the ICU length of stay and ventilatory days if the team follows certain protocols and policies, although other studies have argued against using protocolized weaning. In practical terms, protocols save significant time in the decision-making process and facilitate quicker liberation. All patients need to have a respiratory therapy-driven liberation pathway in place, followed by all patients except when ordered by the physician-in-charge not to follow.[47][48][49]

The American Thoracic Society and the American College of Chest Physicians Clinical Practice Guidelines for Liberation from Mechanical Ventilation in Critically Ill Adults

The summary of these clinical practice guidelines applicable to acutely hospitalized adults on mechanical ventilators for more than 24 hours is as follows:

• Management with a ventilator liberation protocol is suggested.
• Protocolized rehabilitation directed towards early mobilization is suggested.
• Performance of the cuff-leak test is suggested in those who meet the criteria for extubation but are deemed a high risk for the complication of post-extubation stridor.
• Administration of systemic steroids for at least 4 hours before extubation is suggested in those who fail the cuff-leak test but are otherwise ready to be extubated.[42]

Although the recommendations suggested by the American Thoracic Society and the American College of Chest Physicians, published in 2017, are conditional and not strong, they certainly will benefit healthcare professionals in decision-making in the ICU setting. The chapter on the approach to extubation from mechanical ventilation by Alistair Nichol and colleagues in the book "Evidence-Based Practice of Critical Care" is an essential reference for healthcare professionals involved in managing critically ill patients.