Leptospirosis

Etiology

Leptospirosis is caused by an infection with the spirochete bacterium Leptospira. This disease is most often spread through exposure to the urine of infected animals either from direct contact or from contact with soil or water contaminated by the urine. Common animals that transmit Leptospirosis include farm animals such as cattle, pigs, and horses, but they can range from wild animals such as raccoons and porcupines to domesticated dogs.[3][4][5] The more than 160 species of animals found to carry the disease show no signs/symptoms if infected. They can be vectors of disease for several months after inoculation, sometimes never showing any signs/symptoms of infection.

Epidemiology

Leptospirosis typically occurs in a temperate climate, during the late summer or early fall in Western countries, and during the rainy season in the tropics. The incidence in the tropics is almost 10 times that of more temperate climates. This tends to be an unreported disease because its symptoms mimic many other disease processes; however, the World Health Organization has estimated that there are 873,000 cases annually with over 40,000 deaths.[6][7] In the United States, there are 100 to 200 identified cases annually, and most are documented in Hawaii. However, when testing people in urban centers such as Detroit, many tested positive for past infection.

Pathophysiology

Leptospira can invade nonintact skin and mucous membranes. The infection is acquired by coming into contact with infected animals or their infected urine or body tissues. Sometimes Leptospira can even be acquired after contact with contaminated soil and water. Historically, exposures were primarily from recreational water, but more recently the United States has seen an upswing in occupational exposures from agricultural workers. When the organism is shed in the infected animal's urine, it can survive in freshwater for up to 16 days and in soil for almost 24 days. If infected water is inhaled, it can then enter the human host through open wounds, mucous membranes, or the lungs. This disease can also be transmitted across the placenta if an infected human is pregnant, leading to a miscarriage in the first two trimesters. If infected during the third trimester, pregnancy can result in stillbirth or intrauterine death.

Once within the body, the bacteria travels through the lymphatic system and then into the bloodstream. From the bloodstream, the infection can spread to the entire body but tends to settle in the liver and kidneys.

The infected person usually begins to show symptoms in 1 to 2 weeks, but it could take up to a month.

History and Physical

Leptospirosis can present in 2 distinct clinical syndromes, icteric or anicteric.

• The anicteric syndrome is self-limited and presents with a nonspecific flu-like illness. The onset is usually sudden and can include a headache, cough, non-pruritic rash, fever, rigors, muscle pain, anorexia, and diarrhea. The illness may last a few days before the fever resolves. This form of the illness is rarely fatal and represents approximately 90% of all documented cases of Leptospirosis.
• The anicteric syndrome can also have recurrence several days later, and this phase is called the immune stage during which aseptic meningitis can occur.  These patients can recover fully but may suffer from chronic, episodic headaches.
• The icteric phase of leptospirosis is classically known as Weil's disease. This is a severe infection, and the manifestations include fever, renal failure, jaundice, hemorrhage, and respiratory distress. The icteric phase may also involve the heart, CNS, and muscles. This illness is usually severe and may last weeks or months if the patient survives.

The differential diagnosis for Leptospirosis is extremely large and varies from benign processes like viral upper respiratory tract infections and other viral flu-like illnesses to severe infections from rarer "travel" conditions, including Dengue Fever, malaria, Hantavirus, hemorrhagic fevers, and typhoid fever. Also, consider other more common conditions (which one would be likely to consider unless specific exposure history is known) like cholecystitis, mononucleosis, primary human immunodeficiency virus, or, if unvaccinated, measles or rubella.

Evaluation

The diagnosis of leptospirosis is made by growth in a specialized culture or microscopic agglutination test (only available at the Centers for Disease Control [CDC] in Atlanta). Because multiple organ systems are involved, other bloodwork may include renal and liver function tests, coagulation studies, complete blood count, cerebrospinal fluid (CSF), and chest x-rays. If there is a concern for aseptic meningitis in the immune phase, a lumbar puncture to sample the CSF is necessary.[1][8] If questions or concerns arise about how best to make this diagnosis, do not delay treatment if suspected. In severe cases, be sure to contact the CDC or the World Health Organization, which can assist with the collection and transportation of specimens for diagnostic testing.

Treatment / Management

The treatment of leptospirosis depends on the severity. Most experts suggest withholding antibiotics in mild cases. These individuals will benefit from fluids as well as pain and fever control. In outpatient cases, antibiotics that may be used include doxycycline, amoxicillin, or ampicillin.[9][2] If the infection is severe, one may use intravenous penicillin G, third-generation cephalosporins, or erythromycin. Patients with icteric leptospirosis usually need intensive care unit admission as multiple organs can be involved and decompensation can occur rapidly. In the presence of renal failure, corticosteroids may be helpful, but their use is controversial. Respiratory distress due to lung involvement may require mechanical ventilation. Additional therapies include the use of ophthalmic drops, diuretics, and inotropic agents, including renal-dosed dopamine. The mild form of leptospirosis is rarely fatal, but the severe form of Weil disease does carry a high mortality rate.(B3)

Differential Diagnosis

• Brucellosis

• Dengue

• Enterovirus infections

• Hantavirus pulmonary syndrome

• Hepatitis A

• Kawasaki disease

• Malaria

• Measles

• Meningitis

• Q fever