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Anatomy, Head and Neck: Eye Levator Anguli Oris Muscle

Editor: Patrick H. Le Updated: 3/17/2023 8:00:52 PM


A muscle of facial expression, the levator anguli oris, elevates the corners of the mouth. Along with the zygomaticus major and minor, the levator labii superioris, and the levator labii superioris alaeque nasi, it provides upper dental show, primarily during smiling, and for maintaining the resting tone and position of the upper lip. While the levator anguli oris is not the most critical of the smile muscles, unilateral dysfunction of the levator anguli oris can lead to noticeable asymmetry of the smile, which can impact a person's quality of life.[1]

Structure and Function

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Structure and Function

The primary function of the levator anguli oris muscle is to elevate the corner of the mouth, which it achieves in concert with the zygomaticus major muscle, whose effect is to raise and lateralize the oral commissure, moving it obliquely superiorly and laterally. Varying ratios of contraction between the levator anguli oris and the zygomaticus major muscles help define the unique characteristics of an individual's smile. The muscle fibers of levator anguli oris form an angle of approximately 37 degrees with those of the more lateral zygomaticus major muscle.[2] 

Other contributors to the elevation of the upper lip are the levator labii superioris (also known as the quadratus labii) and the levator labii superioris alaeque nasi muscles, which move the lip directly upwards. The zygomaticus minor muscle inserts on the orbicularis oris muscle more medially than the zygomaticus major muscle but still has an oblique vector of pull.[3]

The levator anguli oris, located along with the buccinator and mentalis in the deepest layer of the mimetic muscles, originates roughly 1 cm inferior to the infraorbital foramen within the canine fossa of the maxilla. Its fibers travel in an anteroinferior direction to insert into the modiolus of the oral commissure, a fibrous nexus of muscle interdigitation at the lateral aspect of the orbicularis oris situated at the corner of the mouth. Contributing to the modiolus are the zygomaticus major, risorius, buccinator, depressor anguli oris, orbicularis oris, and levator anguli oris; each of these muscles exerts a force on the oral commissure in a different vector, permitting the myriad variations and nuances of human facial expression.


The levator anguli oris muscles develop alongside the other mimetic muscles of the face, beginning in the third to fourth week of development.[4] The muscles of facial expression arise from the second branchial arch, which also produces the facial nerve, the stapedial artery (which subsequently involutes in most people), and the Reichert cartilage, which in turn becomes the stylohyoid ligament, the lesser cornu of the hyoid bone, and the styloid process of the temporal bone.[5]

Blood Supply and Lymphatics

Branches of the external carotid artery deliver blood supply to the majority of the face, while the internal carotid artery contributes a smaller amount of blood flow, predominantly in the periocular region.[6] The facial artery, a large branch of the external carotid artery, originates in the carotid triangle of the neck before traversing the mandible on its way anterosuperiorly toward the lower face. Various small branches of the facial, internal maxillary, and superficial temporal arteries, all of which arise from the external carotid, supply blood to the levator anguli oris.[2] 

The facial artery provides the lateral nasal artery, which crosses and then runs medially to the levator anguli oris; the internal maxillary artery gives off the infraorbital artery, which runs with the infraorbital nerve (V2) and then emerges from the maxilla through the infraorbital foramen, just superior to the levator anguli oris. The transverse facial branch of the superficial temporal artery also supplies the midface musculature, and some terminal branches may feed the levator anguli oris.[6] 

Venous drainage of the levator anguli oris muscle predominantly flows into the facial vein, which in turn empties into the internal jugular vein. Any blood draining back through the infraorbital vein reaches the pterygoid plexus and proceeds into the retromandibular vein, which frequently joins both the internal and external jugular veins.[6][7]

Following the facial vein, lymphatic fluid from the midface drains into the preauricular, infra-auricular, parotid, nasolabial, buccinator, submandibular, submental, internal jugular, and anterior jugular basins, ultimately into the cervical lymph nodes.[16]


The facial nerve, composed of approximately 10,000 axons, provides motor control of the muscles of facial expression, in addition to the posterior belly of the digastric, the stylohyoid, and the stapedius muscles. Upon emerging from the temporal bone, the facial nerve travels through the parotid gland, separating the deep and superficial lobes, and then continues distally beneath the superficial musculoaponeurotic system (SMAS) of the face. Because the mimetic muscles are contiguous with the SMAS layer, the majority of the muscles of facial expression are innervated from their deep surfaces; the exceptions are the buccinator, the mentalis, and the levator anguli oris muscles, which lie deeper within the face and are therefore innervated from their superficial surfaces.[8] Their innervation source is a terminal buccal branch of the facial nerve that innervates the levator anguli oris muscle.[2]

Surgical Considerations

The position of the levator anguli oris in the medial midface makes it unlikely to be injured iatrogenically, even in major facial surgery, such as rhytidectomy. Lateral rhinotomy or Weber Ferguson approaches to midfacial pathology may place the muscle at risk for injury or, at the very least, edema and inflammation. Primary lesions of the levator anguli oris muscle are rare but reported and might be addressed via an intraoral approach. In 2013, Koltsidopoulos and colleagues described an intramuscular hemangioma within the levator anguli oris muscle in a 26-year-old male who presented with progressive swelling of the right cheek.[9] 

Along with the mentalis and buccinator muscles, the levator anguli oris lies deep to the rest of the muscles of facial expression and is therefore innervated from its deep surface. While few surgical approaches involve dissecting between the levator anguli oris and the overlying zygomaticus minor muscle, the relationship of the terminal facial nerve branches to these muscles should be kept in mind when operating in the medial midface to avoid inadvertent denervation of the levator anguli oris muscle.

Because of the role of the levator anguli oris in maintaining the resting position of the oral commissure, it has been proposed as a target for midfacial rejuvenation procedures, namely plication via an intraoral incision to elevate the corner of the mouth.[2] This technique may find an application in the management of flaccid facial paralysis as well. The levator anguli oris muscle is also a component of interest when undergoing lip repositioning or reconstructive surgeries; the muscular and closely-associated mucosal component makes the levator anguli oris and depressor anguli oris ideal tissue donors for lip defects, especially because sphincter tone can be maintained with the transfer of innervated muscle.[10][11] 

In another reconstructive application, Denewer et al. have described using the levator anguli oris muscle as a pedicle for regional flap transfer into nasal defects. In their technique, the flap is raised via a nasolabial fold incision, including skin and the inferior aspect of the levator anguli oris muscle and intraoral mucosa from the gingivolabial vestibule if necessary. With the muscle remaining attached to the maxilla superiorly, the flap can be tunneled into an ipsilateral nasal defect.[12] The use of the levator anguli oris muscle as a blood supply was also described in 1990 by Takano et al., who reported the removal of the anterior wall of the maxillary sinus as part of a Caldwell-Luc approach, leaving the bone pedicled on the muscle to improve healing postoperatively.

Clinical Significance

The literature has described several uses for the levator anguli oris muscle in both aesthetic and functional surgery. More recently, in 2015, Surek et al. reported a method to analyze the face using the levator anguli oris muscle as a landmark to determine optimal locations for volumizing injections and zones to avoid to minimize the risk of complications.[13] Ultimately, the levator anguli oris is most significant for its critical role in producing a natural-appearing, dentate, or "Duchenne" smile, without which people have difficulty expressing emotion and maintaining human social connection.[14]


(Click Image to Enlarge)
Levator anguli oris
Levator anguli oris
Image courtesy O.Chaigasame



Aoun M, Sleilaty G, Antoun L, Dib R, Chelala D. Duchenne Smile is Associated with Quality of Life and Survival in Hemodialysis Patients. American journal of health behavior. 2020 May 1:44(3):313-325. doi: 10.5993/AJHB.44.3.4. Epub     [PubMed PMID: 32295679]

Level 2 (mid-level) evidence


Ewart CJ, Jaworski NB, Rekito AJ, Gamboa MG. Levator anguli oris: a cadaver study implicating its role in perioral rejuvenation. Annals of plastic surgery. 2005 Mar:54(3):260-3; discussion 263     [PubMed PMID: 15725827]


Bloom J, Lopez MJ, Rayi A. Anatomy, Head and Neck, Eye Levator Labii Superioris Muscle. StatPearls. 2022 Jan:():     [PubMed PMID: 31082075]


Ansari A, Bordoni B. Embryology, Face. StatPearls. 2024 Jan:():     [PubMed PMID: 31424786]


Rodríguez-Vázquez JF, Mérida-Velasco JR, Verdugo-López S, Sánchez-Montesinos I, Mérida-Velasco JA. Morphogenesis of the second pharyngeal arch cartilage (Reichert's cartilage) in human embryos. Journal of anatomy. 2006 Feb:208(2):179-89     [PubMed PMID: 16441562]


Marur T, Tuna Y, Demirci S. Facial anatomy. Clinics in dermatology. 2014 Jan-Feb:32(1):14-23. doi: 10.1016/j.clindermatol.2013.05.022. Epub     [PubMed PMID: 24314374]


von Arx T, Tamura K, Yukiya O, Lozanoff S. The Face – A Vascular Perspective. A literature review. Swiss dental journal. 2018 May 14:128(5):382-392     [PubMed PMID: 29734800]

Level 3 (low-level) evidence


Kochhar A, Larian B, Azizzadeh B. Facial Nerve and Parotid Gland Anatomy. Otolaryngologic clinics of North America. 2016 Apr:49(2):273-84. doi: 10.1016/j.otc.2015.10.002. Epub     [PubMed PMID: 27040583]


Koltsidopoulos P, Tsea M, Kafki S, Skoulakis C. Intramuscular haemangioma of the levator anguli oris: a rare case. Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale. 2013 Oct:33(5):350-2     [PubMed PMID: 24227903]

Level 3 (low-level) evidence


Rao AG, Koganti VP, Prabhakar AK, Soni S. Modified lip repositioning: A surgical approach to treat the gummy smile. Journal of Indian Society of Periodontology. 2015 May-Jun:19(3):356-9. doi: 10.4103/0972-124X.152400. Epub     [PubMed PMID: 26229285]


Tobin GR, O'Daniel TG. Lip reconstruction with motor and sensory innervated composite flaps. Clinics in plastic surgery. 1990 Oct:17(4):623-32     [PubMed PMID: 2249383]


Denewer A, Farouk O, Fady T, Shahatto F. Levator anguli oris muscle based flaps for nasal reconstruction following resection of nasal skin tumours. World journal of surgical oncology. 2011 Feb 18:9():23. doi: 10.1186/1477-7819-9-23. Epub 2011 Feb 18     [PubMed PMID: 21333010]

Level 3 (low-level) evidence


Surek CC, Beut J, Stephens R, Jelks G, Lamb J. Pertinent anatomy and analysis for midface volumizing procedures. Plastic and reconstructive surgery. 2015 May:135(5):818e-829e. doi: 10.1097/PRS.0000000000001226. Epub     [PubMed PMID: 25919264]


Kleiss IJ, Hohman MH, Susarla SM, Marres HA, Hadlock TA. Health-related quality of life in 794 patients with a peripheral facial palsy using the FaCE Scale: a retrospective cohort study. Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery. 2015 Dec:40(6):651-6. doi: 10.1111/coa.12434. Epub     [PubMed PMID: 25858429]

Level 2 (mid-level) evidence