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Anatomy, Shoulder and Upper Limb, Cutaneous Innervation

Editor: Matthew Varacallo Updated: 7/24/2023 4:13:28 PM


Cutaneous innervation of the shoulder and upper limb comes from multiple peripheral nerves originating from cervical and thoracic nerve roots, with most of the nerves originating from the brachial plexus. Location of pain or deficits in sensation can be clinically useful in determining the location of a nerve lesion, especially when combined with an associated motor deficit. This activity will specifically discuss the surrounding anatomy of the nerves providing shoulder and upper limb cutaneous innervation and will be assessing the sensory distribution as it relates to nerve injuries.

Structure and Function

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Structure and Function

The majority of cutaneous and motor innervation of the shoulder and upper limb arise from the brachial plexus, which originates from the C5 to T1 ventral rami.[1][2] There is also a contribution from the supraclavicular nerve of the C3 and C4 ventral rami to the superior aspect of the shoulder and the intercostal brachial nerve of the second and third intercostal nerves in the axilla.

Sensory input can originate from pure sensory nerves as in the case of the medial antebrachial cutaneous, medial brachial cutaneous, and the supraclavicular cutaneous nerves, or from the combined motor and sensory nerves such as the axillary, radial, median, ulnar, and intercostal brachial nerves with their cutaneous branches.[3][4][5] In cases of combined motor and sensory nerves, the motor innervation generally precedes the sensory innervation from proximal to distal.


Supraclavicular Nerve 

Arising from the C3 and C4 ventral rami, the supraclavicular nerve (SCN) courses deep to the sternocleidomastoid muscle and passes through the posterior triangle of the neck, deep to the platysma muscle before dividing into the medial/anterior, intermediate, and lateral/posterior branches which provide cutaneous innervation to the superior, anterosuperior, and posterosuperior aspect of the shoulder.[6][7]

Axillary Nerve

This nerve originates from the posterior cord of the brachial plexus with contributions from the C5 and C6 ventral rami. The axillary nerve travels through the inferior-lateral axilla, and around the surgical neck of the humerus with the posterior circumflex humeral artery.[8][9][10] After providing motor innervation to the deltoid, the axillary nerve gives off the lateral superior cutaneous nerve branch which innervates the lateral skin of the shoulder.[11][12][13]

Musculocutaneous Nerve

The sensory component arises from the musculocutaneous motor nerve, which comes off the lateral cord of the brachial plexus and receives a contribution from the C5 to C7 ventral rami. The musculocutaneous nerve passes from the lateral aspect of the shoulder into the front of the axilla and pierces the coracobrachialis muscle, innervating muscles of the anterior arm. It goes through the deep fascia and continues as the lateral antebrachial cutaneous nerve providing sensation to the lateral forearm from wrist to elbow.[4]

Radial Nerve

The origin of the radial nerve is from the posterior cord of the brachial plexus with contribution from the C5 to T1 ventral rami. It runs posteriorly to the brachial artery and passes through the triangular space to the radial sulcus of the humerus. The posterior cutaneous brachial nerve is the first branch that arises as the radial nerve passes through the axilla, before reaching the radial sulcus. The lateral inferior brachial cutaneous nerve and the posterior antebrachial cutaneous nerve arise from the radial nerve in the radial sulcus. The lateral inferior brachial cutaneous nerve provides sensation to the inferolateral arm, and the posterior antebrachial cutaneous nerve innervates the posterior forearm. As the radial nerve passes across the lateral epicondyle of the humerus, it splits into the posterior interosseous nerve and superficial branch of the radial nerve. It continues under the brachioradialis muscle where it splits again into the medial and lateral branches which give cutaneous innervation to the dorsum of the hand and radial side of the thumb, respectively.[14]

Median Nerve

The median nerve's origin is from the medial and lateral cords from the brachial plexus with contributions from the C6 to T1 ventral rami. It travels with the brachial artery from the axilla and crosses medially to pass through the cubital fossa. Before passing through the carpal tunnel, the median nerve gives off the palmar cutaneous branch for sensory innervation of the lateral palm and the anterior interosseous nerve which provides motor to the majority of the anterior forearm muscles. After passing through the carpal tunnel, the nerve divides again into the recurrent branch of the median nerve to innervate the thenar muscles and the palmer digital branch to provide sensation to the first three digits and radial side of the fourth, and motor to the first and second lumbricals.

Ulnar Nerve

The ulnar nerve derives its origin from the medial cord of the brachial plexus with contributions from the C8 and T1 ventral rami. After passing the axilla, it travels medially to the brachial artery until passing through the intermuscular septum into the posterior compartment. It travels posteriorly to the medial side of the arm and passes through a musculoaponeurotic structure known as the arcade of Struthers to reach the epicondyle of the humerus within the cubital tunnel. Before entering the wrist, the ulnar nerve divides into muscular branches and palmer and dorsal cutaneous nerve branches. The palmer nerve branch supplies sensation over the hypothenar eminence and the dorsal nerve branch supplies sensation to the proximal one-third of the fifth phalanges and ulnar side of the fourth phalanges. The ulnar nerve passes through the canal of Guyon to enter the hand, and it splits into the deep motor branch and cutaneous superficial branch, which innervates the cutaneous skin of the distal two-thirds of the proximal fifth phalanges and ulnar side of the fourth phalanges.

Medial Brachial Cutaneous Nerve

After branching from the medial cord of the brachial plexus with C8 and T1 contributions, this purely cutaneous nerve courses along the medial side of the upper arm, and pierces the deep fascia and supplies innervation to the cutaneous medial upper arm. It has connections with the medial antebrachial cutaneous nerve ulnar branch.

Medial Antebrachial Cutaneous Nerve

This cutaneous nerve branches from the medial cord of the brachial plexus with C8 and T1 contribution. It passes down the anteromedial side of the upper arm and innervates a portion of the cutaneous skin over the anterior upper arm, specifically the skin overlying the biceps brachii.[15] Before reaching the elbow, the nerve courses medial to the brachial artery and eventually divides into ulnar and volar branches.[16] The ulnar branch communicates with the medial brachial cutaneous nerve and provides medial and posterior sensation down the medial forearm to the wrist. The volar branch supplies sensory innervation to the medial and anterior side of the forearm to the wrist.

Intercostal Brachial Nerve:

The intercostal brachial nerve arises typically from the second intercostal nerve and supplies a cutaneous area in the axilla.


Nerve cutaneous distribution can also divide into dermatomes, which breaks sensation into nerve root patterns. Although there is significant overlap between the dermatomes, the general guidelines listed below for dermatome distribution refer to the location at which the nerve root innervation can reliably be isolated from the other nerve roots.[17]

  • C4 nerve root: the superior aspect of the shoulder
  • C5 nerve root: lateral shoulder
  • C6 nerve root: thumb
  • C7 nerve root: third digit
  • C8 nerve root: fifth digit
  • T1 nerve root: medial arm
  • T2 nerve root: axilla

Physiologic Variants

A common variant of the supraclavicular nerve is an absent intermediate branch with larger anterior and posterior branches.[18]

A second or third intercostal brachial nerve innervating a portion of the axilla may arise from the first or third intercostal nerves.[19]

Clinical Significance

Multiple common clinical scenarios can cause damage to the nerves of the shoulder and upper limb, which this activity discusses individually below. Any nerve could be damaged in cases of direct trauma and may be diagnosed clinically based on the sensory pattern of the nerve as outlined previously.

Supraclavicular Nerve

Damage to the supraclavicular nerve branches is a common complication after a clavicle open reduction internal fixation (ORIF). It also can be seen in open clavicle fractures or other trauma, or when compressed due to muscle spasm of the cervical muscular along its course.[20]

Axillary Nerve

Damage to the axillary nerve and its cutaneous branch can present in anterior shoulder dislocation or surgical neck of the humerus fractures.[13]

Musculocutaneous Nerve

Damage to the musculocutaneous nerve is relatively uncommon but can occur with direct trauma such as a stab wound along its course – most often as it passes through the axilla. It can also incur damage during a deltopectoral surgical approach.[21]

Radial Nerve

The radial nerve is particularly disposed to in compression type injuries and humerus fractures due to its proximity to the humerus as it passes through the arm. Fractures to the humerus can cause severe injury requiring repair. It can also suffer an injury due to improper and prolonged use of crutches causing continued pressure on the medial side of the arm or axilla.[3]

Median Nerve

The most common injury to the median nerve is at the carpal tunnel, which is due to compression of the median nerve as it passes underneath the transverse carpal ligament at the wrist. It also can be injured at its passage through the cubital fossa from dislocation of the elbow or an increase in fluid or edema around the elbow secondary to trauma. A distinguishing feature between compression at the elbow compared to compression at the carpal tunnel is sensory involvement over the thenar eminence. In cases of carpal tunnel, the sensation over the thenar eminence is spared due branching of the palmar cutaneous branch before reaching the carpal tunnel. The palmar cutaneous branch passes over the transverse carpal ligament, so would not be affected in carpal tunnel syndrome. Although sensation over the thenar eminence is intact in carpal tunnel syndrome, atrophy of the thenar muscles can be seen in severe cases since the recurrent palmer branch providing motor innervation splits after the nerve passes under the transverse carpal ligament.[22]

Ulnar Nerve

There are multiple sites of compression for the ulnar nerve, which can complicate its diagnosis. From proximal to distal, ulnar nerve compression can occur at the anterior scalene muscles, pectoralis minor muscle, the arcade of Struthers just proximal to the elbow, flexor carpi ulnaris, or as it passes through the tunnel of Guyon. At the elbow, a clinical scenario may be prolonged leaning on the elbow or overuse injuries from exercising. At the wrist, resting of the ulnar side of the wrist during prolonged typing, ganglion cyst formation, or repetitive use of a hammer can cause damage to the nerve.[23][24]

Medial Brachial and Antebrachial Nerves

These purely sensory nerves are rarely associated with specific pathology but suffer damage from direct trauma.

Intercostal Brachial Nerve

Commonly injured during mastectomies or axillary lymph node dissection secondary to breast cancer. Even if it is not injured directly during surgery, post-surgical scar tissue formation can cause compression. Surgeons sometimes harvest this nerve as a donor nerve graft.[25]


The nerve roots that supply the shoulder and upper limb can directly be affected by pathology around the spine in cases of severe osteoarthritis, degenerative disk disease, or ruptured disk. The pattern of sensory changes is observable at the locations noted above in the Structure and Function section. Sensory lesions from the nerve roots can be distinguished from distal pathology due to the pattern of sensory distribution, although it can be difficult, especially in cases where multiple nerve roots are affected. 

Brachial Plexus Injury

Two characteristic conditions associated with brachial plexus injury are Erb's palsy and Klumpke's palsy. The sensory pattern of distribution is typical to the dermatome associated with the nerve roots.

  • Erb palsy is an upper brachial plexus lesion which usually affects the C5 and C6 nerve roots. It is associated with downward trauma over the shoulder or traumatic vaginal deliveries.[26][27]
  • Klumpke palsy is a lower brachial plexus lesion affecting C8 and T1. It is associated with breaking fall from a height by grabbing onto an object with the arm.[5]


(Click Image to Enlarge)
Cutaneous innervation of the shoulder and upper limb
Cutaneous innervation of the shoulder and upper limb
Courtesy From Wikimedia Commons, file: Gray's Anatomy 812 and 814.PNG



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