Binge Eating Disorder

Etiology

Binge eating disorder can result from numerous psychological, social, cultural, and biological factors. Some of the risk factors for binge eating disorder include:[5][6]

1) Childhood obesity

2) Loss of controlled eating in childhood

3) Perfectionism

4) Conduct problems

5) Substance abuse

6) Family weight concerns and eating problems

7) Family conflicts and parenting problems

8) Parental psychopathology

9) Physical and sexual abuse

10) Mental health impairment

11) Mu-opioid (e.g., OPRM1) receptor and dopamine (e.g., DRD2) receptors genes involvement

12) Distorted body image perception

13) Intestinal microbiota alteration

Epidemiology

Binge eating disorder is more common in women than men and usually occurs around the age of 23 years.[7] The lifetime prevalence of this disorder in the United States is 2.6%. Approximately 79% of people with binge eating disorder have one psychiatric disorder; 49% of people possess a lifetime history of two or more comorbid disorders.[7] Prevalent comorbid conditions with binge eating disorder include:[8]

1. Specific phobia (37%)
2. Social phobia (32%)
3. Post-traumatic stress disorder (26%)
4. Alcohol abuse or dependence (21%)

Another analysis showed that of those with more than one diagnosis, 65% had anxiety disorders, 46% had mood disorders, 43% had impulse-control disorders, and 23% had substance use disorders.[9]

Pathophysiology

Binge eating disorder has the same neurobiology as substance use disorder. Research has proposed several models to explain the pathophysiology of binge eating disorder.[10] It occurs due to difficulty in reward processing and inhibitory control. The prominent affect regulation model emphasizes the role of negative affect in binge eating disorder. According to this model, binge-eating episodes are triggered by negative affect and provide relief from them. Difficulties in emotional regulation and reduced emotional awareness have correlations with binge eating disorder. Additionally, interpersonal problems also carry associations with this disorder. Furthermore, neuroimaging studies showed hyperactivity of the medial orbitofrontal cortex and hypoactivity in the prefrontal network in individuals with binge eating disorder.[11][12]  

The food addiction hypothesis states that individuals with high impulsivity and reward sensitivity experience an addictive response to certain foods, for example, high sugar and high-fat foods. Still, they do not develop tolerance or show withdrawal symptoms.[13]

An increased volume of the insula of the left orbitofrontal cortex is a known factor in eating disorders. The insula and frontal operculum are the two regions of the brain that are responsible for processing the basic sensory information about food. The ventral striatum, which includes nucleus accumbens and putamen, and caudate are accountable for evaluating and identifying the rewarding nature of food. The dorsal caudate, ventrolateral prefrontal cortex, parietal cortex, and dorsal anterior cingulate cortex, are the regions of the brain responsible for controlling food-related responses.[14] Patients with binge eating disorder demonstrate low impulse control activity in the prefrontal cortex (PFC), inferior frontal gyrus, ventrolateral PFC, and the insula.[15]

Polymorphism in the serotonin transporter dopamine receptor D and mu-opioid receptors have links to binge eating disorder.[16]

History and Physical

History[4]

The clinician should inquire about the following points to help diagnose patients with binge eating disorder.

1) Age of onset of binge eating episodes

2) Frequency of binge eating episodes

3) Duration of episodes

4) Amount of food

5) Feelings associated with binge disorder

6) Any compensatory behavior (vomiting, purging, laxative use)

7) Comorbid conditions (psychological problems, obesity, diabetes)

8) Emotional triggers (abandonment and stress)

9) Societal pressure

10) Media input (binge eating as an acceptable method to cope with stress)

11) Childhood emotional abuse

12) Childhood restriction of calorie intake or disordered eating behavior in childhood

13) Suicidal ideation

14) Substance misuse

15) Physical and sexual abuse

16) Body image perception

15) Family history of binge eating

Physical Examination

The patient should have an examination to assess for comorbidities associated with obesity due to binge eating disorder.

i) Blood pressure requires regular checking.

ii) Blood glucose requires regular monitoring.

iii) Examine for physical or sexual abuse if there is high suspicion.

The tools commonly used to evaluate binge eating disorder are as follows:

1) Binge eating scale

2) Three-factor eating questionnaire

3) Body shape questionnaire

4) Eating disorders examination (EDE)

5) Structured clinical interview for the diagnosis of DSM disorders

6) Questionnaire of eating and weight patterns

Evaluation

The evaluation of the patient with binge eating disorder includes the psychiatric, medical, and nutritional evaluation of the patient. 

Psychiatric Status

Patients should have an evaluation for:

a) Psychiatric comorbidities (depression and substance abuse disorder)

b) Person image of body shape and weight

c) Self-esteem

Medical Status

Medical status evaluation should include comorbidities and parameters associated with obesity and excess body weight which are:

a) Waist circumference

b) Body mass index (measure height and weight)

c) Hypertension

d) Hyperlipidemia

e) Diabetes mellitus

f) Gastroesophageal reflux disease

g) Hepatobiliary disease

h) Coronary artery disease

i) Obstructive sleep apnea

j) Hypothyroidism

Nutritional Status

Assess the nutritional status of the person by asking:

a) Dieting and lifetime weight history

b) Physical activity and exercise

c) Current eating pattern and choice of food

d) Intensity and frequency of binge eating episodes

f) Types of overeating (overeating at meals, night eating, snacking, and grazing)

Treatment / Management

The type of treatment provided to binge eating disorder, treatment setting, and healthcare person involved in the therapy of patients with binge eating disorder depends upon treatment goals. Treatment goals may include working on:

1) Excessive body weight

2) Binge eating episodes

3) Extreme concern for body image

4) Comorbid psychiatric conditions (anxiety, substance use disorder, and depression)

Available treatment options for binge eating disorder include:

1) Psychotherapy

2) Pharmacotherapy

3) Weight loss treatment

1) Psychotherapy:

Psychotherapy is the first-line treatment option for binge eating disorder. According to several clinical trials, psychotherapy has a more significant clinical effect than pharmacotherapy. Common psychotherapy options are:

a) Cognitive-behavioral therapy

b) Interpersonal psychotherapy

c) Dialectical behavioral therapy

A) Cognitive Behavioral Therapy (CBT): 

CBT is the psychotherapy of choice for binge eating disorder based on the results of several randomized controlled trials. The patient can receive CBT either from a clinician or through a self-help program without clinician involvement. Research shows that CBT has higher abstinence, is well-tolerated, and maintains remission for 1 or 2 years. A quick change in symptoms of patients with binge eating disorder is a good prognostic sign. Binge eating disorder patients with comorbid anorexia nervosa or bulimia nervosa do not respond well to CBT.[17](A1)

Self-help based CBT is as effective for treating binge eating disorder as clinician-led CBT. Treatment settings have an effect on self-help based CBT. Delivering self-help based CBT in specialty settings, for example, eating disorder clinics, is more effective than delivering in a primary care setting. A self-help program focuses upon creating a regular pattern of eating, monitoring eating habits, learning self-control techniques, and learning problem solving more effectively. Hardcopy, web-based content, workbook, or smartphone application can be used to implement this program.[18][19] These materials provide:(A1)

i) Step by step approach to therapy

ii) Education regarding binge eating disorder.

B) Interpersonal Psychotherapy: 

Interpersonal psychotherapy can take place in a group format or individual format. Psychotherapy does not focus on weight loss, but weight changes do occur due to stopping binge eating. It can also be provided in combination with CBT if the patient has complex psychopathology that may include interpersonal problems, low self-esteem, and perfectionism.[8][20][21] The following are the steps of the therapeutic strategy of psychotherapy:(A1)

i) Identify the area (most probably interpersonal area) that links to binge eating disorder.

ii) Focus mainly on experimentation or constructive changes in the problematic relevant regions (interpersonal) with little focus on binge eating.

C) Dialectical Behavioral Therapy: 

Dialectical behavioral therapy consists of educating patients about the skills which are needed to manage problematic behavior associated with emotional dysregulation.[22] This therapy helps patients in balancing the dichotomous feelings, behavior, and thinking. The skills highlighted in this therapy include:(A1)

i) Watchful eating

ii) Emotional balance

iii) Tolerance of unpleasant circumstances

iv) Prevention of relapses

2) Pharmacotherapy: 

Pharmacotherapy should be used as first-line therapy in patients who:

i) Do not have access to psychotherapy

ii) Decline psychotherapy

iii) Prefer medications

Medications that can be useful for binge eating disorder include:

i) Selective serotonin reuptake inhibitors (SSRIs) - sertraline, fluoxetine, fluvoxamine, escitalopram, citalopram

ii) Antiepileptic drugs - zonisamide and topiramate

iii) Attention deficit hyperactivity disorder (ADHD) medications - lisdexamfetamine, and atomoxetine)

iv) Medication for shift work disorder - armodafinil

v) 

Selective serotonin reuptake inhibitors (SSRIs) should be the first-line pharmacotherapy for binge eating disorder. Antiepileptic medications or medications used for ADHD are an option if a patient fails one or two courses of SSRI. Randomized controlled trials have reported a promising role of topiramate, lisdexamfetamine, and methylphenidate in causing abstinence from binge eating disorder as well as in weight reduction. Limitations for using these medications have been due to the side effects of these medications. Topiramate can cause somnolence, paraesthesias, and cognitive impairment. Lisdexamfetamine and methylphenidate may cause anorexia, gastrointestinal disorder, headache, insomnia, sympathetic nervous system arousal, as well as dependence, and potential misuse.[23][24][25] Lisdexamfetamine is FDA-approved for the treatment of moderate to severe BED in adults aged 18 to 55. (A1)

3) Obesity or weight loss treatment: Most of the patients with binge eating disorder seek treatment for weight reduction rather than binge eating. All obese patients should be evaluated closely for binge eating disorder.[8] (A1)

i) Low and very low-calorie diet and exercise is the best option for losing weight. Behavioral weight loss therapy is a strategy designed to reduce binge eating as a result of weight loss indirectly. A randomized controlled trial concluded that behavioral weight loss therapy showed remission of binge eating disorder in 44 percent of patients. Moderate calorie restriction, exercise, and improved nutrition with nutritional counseling and rehabilitation are some of the specific components of behavioral weight loss therapy.

ii) Pharmacotherapy provides short-term weight loss in obese patients. Different classes of medications exert different clinical effects. Pharmacologic agents should be chosen based on patient preference, patient comorbidities, potential adverse effects, and insurance coverage, cost of medication of choice for obesity include:

a) Lorcaserin and liraglutide (daily injections)

b) Orlistat

c) Combination phentermine-extended release topiramate

d) Combination naltrexone-bupropion

e) Phenteramine

f) Benzphenteramine

g) Phendimetrazine

h) Diethylpropion

iii) Bariatric surgery can also be helpful for obese patients with binge eating disorder. Binge eating after bariatric surgery is associated with poor weight outcomes.

iv) Psychotherapy has no role in reducing weight in obese patients with binge eating disorder.

Differential Diagnosis

Diseases that come under the differential diagnosis of binge eating disorder are as follows:

• Bulimia nervosa - Binge eating disorder differs from bulimia nervosa in that there is no compensatory behavior (laxative misuse, fasting, or self-induced vomiting) after eating to prevent weight gain
• Anxiety disorder - Anxiety disorder also has associations with binge eating; however, the patient will only receive a diagnosis of binge eating disorder when binging episodes occur every week for three months
• Kleine-Levin syndrome - Episodes of binges associated with excessive sleep
• Mood disorder - Episodes of binges occur with other psychological features of mood disorder

Prognosis

Long-term outcome studies of binge eating disorder demonstrate that the prognosis of binge eating disorder is better than other eating disorders with a more favorable remission rate. The tendency of binge eating disorder to convert to other eating disorders is very small. Only a few studies have reported increased odds of migration to bulimia nervosa. Depressive symptoms and substance abuse are two significant adverse mental health outcomes of binge eating disorder.[26]

Binge eating disorder in childhood predicts excess weight gain in adolescent and young women. It also independently increased the risk of obesity-related complications, for example, metabolic syndrome.[27][28][29]

Complications

Most of the patients with binge eating disorder are obese. Binge eating disorder and obesity, most of the time, coexist and share complications.[4][30] The complications of these two disorders include:[31][32][33]

1) Muscular pain

2) Neck, shoulder, and lower back pain

3) Impairment resulting from physical health problems after adjustment of BMI

4) Hypertension

5) Diabetes

6) Asthma - respiratory illness

7) Coronary artery diseases and heart failure

8) Hyperlipidemia

9) Weight gain

10) Menstrual dysfunction (amenorrhea, oligomenorrhea)

11) Cortisol hormones disbalance (blunted cortisol response to stress test and decreased urinary cortisol levels)

12) Cancer (colon, breast, endometrial, gall bladder, and other)

13) Osteoarthritis

14) Sleep apnea

15) Obesity hypoventilation syndrome

16) Non-alcoholic fatty liver disease

17) Gallbladder disease

18) Metabolic syndrome