Anatomy, Abdomen and Pelvis: Inferior Vena Cava

Structure and Function

The inferior vena cava is ultimately responsible for the transport of almost all venous blood (deoxygenated) from the abdomen and lower extremities back to the right side of the heart for oxygenation.

Embryology

During the fifth week of embryologic development, there are 3 major identifiable pairs of veins: the vitelline veins, the umbilical veins, and the cardinal veins. Only the vitelline veins and the cardinal veins contribute to the formation of the inferior vena cava in the human adult.

The vitelline veins, also known as the omphalomesenteric veins, form a plexus around the primitive duodenum and pass through the septum transversum to drain venous blood from this area. As liver cords grow into the septum transversum a dense, sinusoidal network forms and the left vitelline vein regresses. The sinusoidal network becomes the hepatic sinusoidal system, and the plexus around the duodenum becomes the portal vein. While the left vitelline vein regresses, the right vitelline vein becomes more prominent and is called the hepatocardiac channel.[3]

The hepatocardiac channel forms the hepatocardiac portion of the inferior vena cava.  

The cardinal veins, which are primarily responsible for venous drainage of the early embryo, are paired veins divided into anterior and posterior segments. The anterior cardinal veins drain the cephalad portion of the embryo, and the posterior cardinal veins drain the caudal portion. Sometime between the fourth and fifth weeks of embryologic development the subcardinal veins, the sacrocardinal veins, and the supracardinal veins are derived from the cardinal veins. These derivatives of the cardinal veins play an important role in the formation of the inferior vena cava.

The supracardinal veins assume the role of the posterior cardinal veins and drain the body wall by becoming intercostal veins. Supracardinal veins do not directly contribute to the formation of the inferior vena cava.

The left subcardinal veins coalesce to form the left renal vein and left gonadal vein. The right subcardinal vein becomes the renal portion of the inferior vena cava.

The sacrocardinal veins coalesce to form the left common iliac vein. The right sacrocardinal vein becomes the sacrocardinal segment of the inferior vena cava.

The union of the renal portion of the inferior vena cava with the hepatocardiac portion of the inferior vena cava completes the embryologic formation of the inferior vena cava with its hepatic, renal, and sacrocardinal segments.[4]

Blood Supply and Lymphatics

Blood supply to the inferior vena cava is derived partially from the deoxygenated blood it carries towards the heart and partially supplied by the vasa vasorum that penetrates the tunica adventitia of the vessel.[5]

Nerves

The inferior vena cava receives autonomic innervation from the splanchnic nerves.[6] This innervation serves to alter the diameter of the IVC via interactions with alpha-1, alpha-2, and beta-2 receptors.

Muscles

As in all vasculature, the inferior vena cava contains three layers: the tunica intima, the tunica media, and the tunica adventitia. The tunica media layer of the inferior vena cava contains smooth muscle responsive to the input from the nervous system.[6] No other muscles are found in the inferior vena cava.

Physiologic Variants

There are many physiologic variants of the IVC.[1] Compared to the arterial system the venous system is much more susceptible to congenital malformations, many of which remain asymptomatic throughout a patient's life. If symptoms are present, they are often vague and include abdominal pain or low back pain. Some of the more clinically significant physiologic variants are listed below.

• Left Inferior Vena Cava: This anomaly is caused by the regression of the right supracardinal vein and the persistence of the left supracardinal vein. The left inferior vena cava is joined by the left renal vein and then crosses anterior to the aorta before it joins the right atrium, forming a normal pre-renal IVC. This anomaly has a suspected prevalence of 0.2% to 0.5%.
• Double Inferior Vena Cava: This anomaly is caused by the persistence of both the left and right supracardinal veins. A prevalence of 0.2% to 0.3% is suspected. [7]
• Intrahepatic Inferior Vena Cava Agenesis: Congenital anomaly resulting in the lack of the intrahepatic IVC. Intrahepatic venous supply bypasses the hepatic IVC through the azygos/hemiazygos venous system.[2]
• Absent Infrarenal Inferior Vena Cava: This is the rarest of the physiologic caval anomalies. The suspected and currently accepted etiology of absent infrarenal inferior vena cava is intrauterine or perinatal thrombosis and resultant degeneration of the infrarenal IVC.[8]

Surgical Considerations

Any surgical procedure involving the thoracic cavity or abdomen requires attention to the location, condition, and orientation of the inferior vena cava in relation to other structures and organs.  Anatomic variants of the IVC are not common, but awareness of their presence and associated diseases/other common co-existing anomalies is important. Unmitigated injury to the IVC, either iatrogenic or resultant of trauma, results in rapid exsanguination. The principles of repair for injury to the IVC is similar to other vessel injuries. Although there are varying techniques depending on the location of the injury and the experience of the surgeon the primary objective is proximal and distal control of the IVC followed by some type of repair. In a life-threatening situation, IVC ligation has been successfully undertaken. This is a last resort procedure and comes with significant morbidity if the patient survives.

Clinical Significance

Although there is some controversy over indications, recurrent deep venous thromboses and consequent pulmonary emboli refractory to treatment with anticoagulation may require placement of an inferior vena cava filter.[9] Certain institutions also advocate for IVC filter placement for high-risk trauma patients (even without documented clots). IVC filters may be permanent or retrievable, although data suggest that only a fraction of the retrievable filters are later removed. Anatomic variations from the norm require careful attention to detail and understanding of their manifestations and potential complications during procedures.

IVC thrombosis is a difficult clinical scenario. Although it can be asymptomatic IVC thrombosis can also present with a myriad of symptoms. These are usually non-specific like abdominal or back pain; but may also include leg cramping, swelling, or pain. Treatment is based on patient condition/symptoms and can include anticoagulation, clot, and/or filter (if present) removal via Interventional Radiology techniques or rarely open surgical techniques. The most common cause of IVC thrombosis in a patient without anatomic variants is the previous IVC filter placement.[10]