Emulsions

Issues of Concern

Emulsions are a sub-class of colloids, which are two-phase systems of matter.

Although the terms colloid and emulsion are sometimes used indistinctly, emulsion applies only when both dispersed, and continuous phases are liquids. A colloid is a mixture of a compound that is in a solid, liquid, or gas state and a liquid. The critical difference between a colloid and an emulsion is that colloid can form when any state of matter (solid, gas, or liquid) combine with a liquid. In contrast, the emulsion has two liquid components that are initially immiscible with each other.

Emulsions, as liquids, do not demonstrate a static internal structure. Emulsions are thermodynamically unstable as both the dispersed and continuous phases can revert as separate phases, oil, and water, by fusion or the coalescing of droplets. Industries use emulsifying agents, eg, surfactants, to maintain a static structure.[1] 

Usually, the phase in which the surfactant exhibits the greatest solubility is the continuous phase. Thus, hydrophilic surfactants foster O/W emulsions, whereas lipophilic surfactants promote W/O emulsions.

Clinical Significance

Emulsions are frequently used in pharmaceuticals, personal hygiene products, and cosmetics. These are usually oil and water emulsions, albeit dispersed. These emulsions are called creams, ointments, balms, pastes, films, or liquids, depending on their oil-to-water ratios, the addition of other additives, and their intended administration route. Emulsions allow the encapsulation of an active ingredient in the dispersed phase to protect it from degradation and preserve its activity in a sustained manner. They are used to make medications more palatable, to improve their effectiveness via dosage control of active ingredients, and to provide better aesthetics for topical drugs such as ointments.

Intravenous and parenteral emulsions may be used for nutritive therapy applications when a patient is unable to consume food or receive nutrition. Fat emulsions serve as dietary complements for patients who cannot get the required fat solely from their diet. The compound may be given as a tablet, capsule, granule, or powder for oral administration.

Nanoemulsions are nano-sized emulsions manufactured to improve the delivery of active pharmaceutical ingredients.[2] Microemulsions form spontaneously and are thermodynamically stable. Thermal stability is not true for nanoemulsions, which are somewhat more stable than standard emulsions, but only kinetically stable. The two systems differ significantly since nanoemulsions form by mechanical shear, and microemulsion phases form by self-assembly.

Microemulsions are a vehicle by which to deliver vaccines or kill microbes. Emulsions utilized in these techniques are soybean oil nanoemulsions, with particles in the range of 400 to 600 nm in diameter. The process of creating these microemulsions is not chemical, as with other types of antimicrobial treatments, but mechanical. The smaller the droplet, the more significant the surface tension and, thus, the more significant the force required to merge with other lipids.[3] 

The oil is emulsified using a high-shear mixer to stabilize the emulsion so that when the droplets come in contact with lipids in a cell membrane of bacteria or the envelope of a virus, they cause the lipids to merge with themselves. This action disintegrates the membrane and kills the microbe. The soybean oil emulsion is not toxic to healthy human cells or the cells of most other higher organisms, except for sperm cells and blood cells, which are vulnerable to nanoemulsions due to the singularity of their membrane structures. These nanoemulsions are not currently used intravenously because they could potentially cause sterility. The most useful application of this nanoemulsion type is for surface disinfection. Some nanoemulsions have effectively destroyed HIV-1 and tuberculosis pathogens on non-porous surfaces.[4]

The submicron emulsions, an isotropic mixture of drugs, lipids, and surfactants with hydrophilic co-solvents and droplet diameters ranging from 10 to 500 nm, are of increasing interest in medicine due to their kinetic stability, high solubilizing capacity, and tiny globule size.[5] They are designed mainly for applications in controlled or sustained drug delivery, targeted delivery, taste masking, bioavailability enhancement, and enzyme immobilization.[6]

Nursing, Allied Health, and Interprofessional Team Interventions

Emulsions are in widespread use, and acquiring sufficient knowledge about them is prudent for all healthcare professionals. Nurses, pharmacists, and physicians work with emulsions in various formats and can provide better patient safety and efficacy if they understand their characteristics and applications.