Coronary Sinus Thrombosis

Etiology

Like thrombosis at any other site, coronary sinus thrombosis results from a combination of venous stasis, alteration of the coagulation profile, and vessel wall injury, such as endothelial damage. The following invasive right heart procedures have all been implicated in the etiology and pathogenesis of coronary sinus thrombosis.

• Central venous catheter placement
• Coronary sinus instrumentation for ventricular lead placement during cardiac resynchronization
• Coronary sinus cannulation for retrograde cardioplegia during cardiopulmonary bypass for cardiac surgery (such as heart transplantation mitral valve replacement)
• Biventricular defibrillator placement in severe cardiomyopathy, 
• Electrophysiologic ablations for arrhythmias such as supraventricular tachycardias
• Ventriculoatrial shunt insertion for hydrocephalus [1][2][3][4][5][6][7][8][9]

The common factor in the etiopathogenesis of all these cases has been endothelial injury leading to thrombosis. Spontaneous non-iatrogenic coronary sinus thrombosis cases that do not involve endothelial injury but rather involve either venous stasis or alteration in coagulation profile have been documented in association with preexisting disease processes, including:

• Atrial fibrillation
• Right heart failure
• Tricuspid regurgitation
• Chronic obstructive pulmonary disease
• Chronic cor pulmonale due to pulmonary fibrosis
• Kawasaki disease
• Acute lymphoblastic leukemia [10][11][12][13]

This condition has also been documented as a complication of infective endocarditis, specifically fungal endocarditis. Sepsis and disseminated coagulopathy play an additional role in precipitating spontaneous coronary sinus thrombosis. Embolic sequela of an intra-abdominal infectious process and, recently, Crohn disease are also reported to be associated with spontaneous coronary sinus thrombosis.[11] Prior cases of coronary sinus thrombosis resulting from massive atrial thrombosis extending into the coronary sinus have also been reported.

Epidemiology

The occurrence of coronary sinus thrombosis is rare or at least rarely reported. However, out of the published cases, acute ones are more common (more than 80) than chronic ones. Considering the high number of patients who undergo ventricular pacing via the coronary sinus with ventricular pacemakers, the lack of reports of coronary sinus thrombosis is often surprising. Because ventricular pacemakers are usually implanted in reasonably sick patients with severe cardiomyopathy, sudden death is unlikely to be investigated with a postmortem study. In at least a few of these, the possibility that thrombosis of the coronary sinus could be associated with cardiac death remains unanswered.

No clear male or female predominance was reported. Coronary sinus thrombosis is likely under-recognized because of the rapid deterioration of these patients and the limited overall clinical experience of cardiologists with this condition. Most acute cases are usually fatal and often diagnosed on autopsy, and this curtails the reported incidence and prevalence of this condition.

Pathophysiology

The heart's venous drainage consists of 3 separate systems (see Image. Coronary Sinus of the Heart). The first major system is the coronary sinus, which receives approximately 60% of the total cardiac venous return from the posterior myocardium via several tributaries and opens into the right atrium. The second system consists of the anterior cardiac veins, which open into the right atrium and drain most of the remaining 40%. There are many anastomotic connections between these 2 systems.

Lastly, the heart is also drained by a third minor system, the thebesian veins, consisting of many small veins, venae cordis minimae, that drain directly into all heart chambers. Sometimes, the thebesian vessels can drain up to 50% of the total cardiac venous return. Therefore, considering these anastomotic connections between the coronary sinus and the anterior cardiac veins and the drainage capability of the thebesian veins, coronary sinus thrombosis would theoretically appear to be a relatively benign entity, but it is not.

"Corona" means crown in Latin. Since this vessel forms a partial crown-like circle around the heart, it is aptly named "Coronary." The length and diameter of the coronary sinus are variable. The overall size is affected by several factors, such as the body's volume status, preload from the venous return, preexisting history of heart disease or heart surgery, and the amount of atrial myocardial tissue contributing to the vessel wall.

The coronary sinus is formed by a collection of veins joined together to form a large bore vessel, the coronary sinus, that collects blood from the heart muscle.[14] The coronary sinus has the following tributaries:

• Great cardiac vein
• Oblique vein of the left heart
• Posterior vein of the left ventricle
• Middle cardiac vein
• Small cardiac vein

The mechanism involving coronary sinus thrombosis has been suspected to be similar to thrombosis at other sites. For example, endothelial damage, hypercoagulability, and venous stasis—a triad proposed by Virchow in 1856—have been involved. Previously described cases of coronary sinus thrombosis have involved each of these factors. The most common mechanism for triggering thrombosis is endothelial damage during invasive cardiac procedures. Spontaneous thrombosis may be chronic stasis (atrial fibrillation) or hypercoagulable (malignancy).

Acute coronary sinus occlusion causes abrupt elevation of the transcapillary pressure, which, in turn, causes increased myocardial perfusion pressure even in the presence of normal, healthy coronary arteries. In addition, the venous and capillary engorgement may directly result in direct myocardial injury. Both mechanisms may lead to a transudative effusion.[15] This rapid increase in myocardial perfusion pressure decreases coronary artery blood flow, inducing ischemia, arrhythmia, progression to infarction, and sudden cardiac death.

Chronic nonocclusive coronary sinus thrombosis may not increase coronary venous pressures to the same degree but is at risk of embolization, extension into the right atrium, and fragmentation, which may also embolize to the pulmonary artery, or the systemic circulation in the presence of an atrial septal defect. Chronic progressive occlusion has also been described to be well tolerated, probably due to efficient collateral circulation between the coronary sinus, anterior cardiac, and Thebesian venous systems. On rare occasions, it could be asymptomatic without any signs of overt ischemia.

History and Physical

A high index of clinical suspicion is required to consider coronary sinus thrombosis in the diagnosis as the symptoms are not well characterized due to the shortage of published cases and relatively high mortality rate. Results from early studies have shown that occlusion of the coronary sinus resulted in chest pain, shortness of breath, hypotension, ischemic electrocardiogram changes such as ST-segment elevations, pericardial effusion, cardiogenic shock, or even sudden cardiac death. Mortality is high due to the nonspecific clinical presentation, rapidity of clinical deterioration, and rarity of the condition.[6][16]

Occasionally, a few cases have an insidious onset and form a partial or incomplete thrombus. Such partial or incomplete occlusion of the coronary sinus by chronic thromboses may not cause immediate death due to the formation of adequate collateral circulation among the coronary sinus, anterior cardiac vein, and Thebesain veins. Therefore, chronic occlusion of the coronary sinus with thrombus remains silent without any signs of myocardial decompensation until further complications, such as progression to complete occlusion or rupture and embolization of the thrombus develop, causing potential pulmonary embolism or myocardial dysfunction or infarction.

Evaluation

If dilated, the coronary sinus is seen on transthoracic echocardiography in the parasternal long-axis view and apical 4-chamber view; it is even more reliably visualized on transesophageal echocardiography in a modified mid-esophageal 4-chamber and bi-canal views.[14][17][18] On the other hand, asymptomatic chronic coronary sinus thrombosis in patients is detected incidentally on computed tomography scan angiography or routine echocardiography done for other purposes. In acute severe cases where sudden cardiac death results, it is found on autopsy if one is done promptly. In most acute coronary sinus thrombosis deaths, the antemortem diagnosis was not made due to lack of clinical suspicion until autopsy findings of thrombosed coronary sinus were discovered.

Treatment / Management

Unfortunately, the management of coronary sinus thrombosis is also poorly described. The role of aspirin is doubtful. Coronary sinus thrombectomy in acutely ill patients, followed by anticoagulation with heparin bridge to warfarin therapy, has been utilized in both stable and unstable patients. Anticoagulation alone with low-molecular-weight heparin as a bridge to warfarin or novel oral anticoagulant therapy has also been employed in clinically stable patients.[13] Although healthcare professionals use the above treatment modalities with reasonable benefit, there is insufficient literature to elucidate any mortality or morbidity benefit from such treatments. Clear, concise guidelines to facilitate management in the long run and the role of anticoagulation therapy, especially novel oral anticoagulants, require further clinical studies.

Differential Diagnosis

Due to the nonspecificity of the clinical presentation and limited experience with coronary sinus thrombosis, it is usually not very high on the list of differential diagnoses. The following possible differential diagnoses need to be considered.

• Myocardial infarction: With a presentation of chest pain, dyspnea, hypotension, tachycardia, elevated troponins, and ischemic changes on the echocardiogram, myocardial infarction due to coronary artery disease is high on the differential. Coronary sinus thrombosis can also present with a similar picture. However, a coronary angiogram can differentiate both conditions and diagnose coronary sinus thrombosis. Establishing a clear cause and diagnosis is critical as the management of myocardial infarction due to coronary artery disease is very different from myocardial infarction due to coronary sinus thrombosis.
• Pericardial effusion and tamponade: Differentiating pericardial effusion due to coronary sinus thrombosis from pericardial effusion due to multiple other causes, such as cancer, infection, or autoimmune disorders, is important as the management differs significantly according to the etiology.
• Septic shock: Acutely decompensated cases with coronary sinus thrombosis can present with a cardiogenic shock, which has to be differentiated from septic shock. Clinical parameters like the source of infection, signs of sepsis, labs, and investigations about sepsis workup should help distinguish both conditions.
• An incidental dilated coronary sinus due to thrombosis has to be differentiated from other causes of coronary sinus dilation, such as congenital disorders causing an abnormally increased venous return to the coronary sinus. These include patent left superior vena cava, anomalous hepatic and pulmonary venous drainage, and coronary arteriovenous fistulae. A dilated coronary sinus can also be seen in right heart failure with ventricular dysfunction and conditions causing increased right atrial pressure, such as pulmonary hypertension.

Prognosis

The prognosis is poor, especially in acute presentations, with more than 80% of patients developing devastating complications, as mentioned earlier, resulting in cardiac death. However, asymptomatic individuals with an incidental diagnosis of chronic coronary sinus thrombosis are less reported than acute ones, and the prognosis is better on aggressive treatment with adequate anticoagulation with or without thrombectomy.

Complications

Coronary sinus thrombosis can have devastating fatal complications such as acute myocardial ischemia, myocardial infarction, pulmonary embolism, pericardial effusion, cardiac tamponade, cardiogenic shock, and even sudden cardiac death if early diagnosis and treatment is not initiated.[7][9]