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Benign Florid Vascular Proliferation Mimicking Vascular Neoplasm

Editor: Yurong Wheeler Updated: 6/26/2023 9:00:30 PM


Vascular lesions or tumors are uncommon in the gastrointestinal tract.[1] Florid vascular proliferation (FVP) within the gastrointestinal tract is a benign and reactive process that can mimic other benign or malignant vascular tumors.[2][3][4] Florid vascular proliferation was first described in 1993 by Ramsden et al. in a patient with repeated abdominal pain and intussusception where “florid vascular proliferation” that mimicked a primary angiomatous lesion was identified.[5] On gross examination, most florid vascular proliferations appear as an exophytic, sessile, or polypoid mass with a conglomerated nodular or nodule-aggregating appearance with thickened mucosa and focal hemorrhages.[3] Tissue biopsy or complete lesion excision with the microscopic examination is usually necessary for a definitive diagnosis. Complete surgical excision is the treatment of choice.


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Colonic florid vascular proliferation is most commonly associated with intussusception and colonic obstruction. The literature review has also demonstrated the association of florid vascular proliferation with mucosal prolapse, lipomas, human immunodeficiency virus, cytomegalovirus, and Meckel diverticulum.[6][7]


Florid vascular proliferation usually involves middle-aged and older adults, but there have been some cases in infants with cytomegalovirus infection.[5][3] The most common site for occurrence is the colon, followed by the small intestine, appendix, and Meckel diverticulum.[8][9][3]


The possible mechanisms for florid vascular proliferation include, continued mechanical forces on the bowel wall as encountered in intussusception; or maintained stresses on a chronic ulcer, which in turn leads to bowel hypoperfusion and/or ischemia and ultimately reactive vascular proliferation.[5]


Histologically, florid vascular proliferation demonstrates granulation tissue-type florid proliferation of small vascular channels in a lobular arrangement. The vascular channels' lining is plump endothelial cells involving the entire thickness of the bowel wall, expanding from the submucosa to subserosal connective tissue. The endothelial cells have mild nuclear atypia with few to no mitosis. The overlying mucosa of the lesion demonstrates ulceration with ischemic-type changes and some features of mucosal prolapse with underlying fibrosis.[3][5] Focal areas of organizing thrombus-like changes may present. With immunohistochemical stains, the vasculature endothelial cells are positive for CD31 and CD34 and negative for HHV-8.[9]

History and Physical

The most common site of florid vascular proliferation is a colon, which explains most of the symptoms associated with this lesion. Patients usually present with abdominal pain, melena, diarrhea, and sometimes bleeding. In some cases, when the size of the lesion is large, patients may also present with a "mass" effect, demonstrating signs and symptoms of bowel obstruction or intussusception.[5]


Although different radiology diagnostic modalities such as barium enema, CT scan, magnetic resonance imaging (MRI) and colonoscopy, can be used to demonstrate a possible "mass" in the gastrointestinal tract, none of these techniques are specific.[5][[7] A definitive diagnosis of FVP can only be achieved by tissue biopsy with microscopic examination. And in most cases, complete resection of the lesion is needed for a correct diagnosis.

Treatment / Management

In symptomatic cases, complete surgical excision is the treatment of choice. Since florid vascular proliferation is a benign reactive lesion, there are no reports of reoccurrence reported in published English literature, and no additional treatment is required postoperatively.

Differential Diagnosis

The most crucial entity in the differential diagnosis is angiosarcoma. The gastrointestinal angiosarcoma is rare, and it usually involves the small intestine. Angiosarcoma is composed of atypical epithelioid tumor cells arranged in solid sheets with only subtle vasoformation. Brisk mitosis and necrosis are common presentations in angiosarcoma.  However, florid vascular proliferation usually demonstrates a more obvious capillary architecture in a lobular growth pattern. Mitosis is none or infrequent. The endothelial cells in FVP do not have significant cytologic atypia. Furthermore, the finding of mucosal prolapse-type changes, such as muscular fibroplasia, is very helpful for a diagnosis of FVP. The diagnosis of angiosarcoma of the GI tract is only possible after the exclusion of florid vascular proliferation and other benign vascular lesions.[3]

The second entity in the differential diagnosis is Kaposi sarcoma (KS). Kaposi sarcoma is a malignant neoplasm associated with human herpesvirus-8 (HHV-8), usually involving patients with immune deficiency.[1] Microscopically, the morphologic features that differentiate Kaposi sarcoma from florid vascular proliferation are compressed, slit-like vascular channels with extravasated erythrocytes, hemosiderin, and plasma cells. Mitoses are common, but nuclear pleomorphism is usually minimal in Kaposi sarcoma.  Positive HHV-8 immunostain can also help to differentiate Kaposi sarcoma from florid vascular proliferation. 

Other benign vascular lesions, such as hemangiolymphangiomas (HLAs), vascular malformations, or angiogenic polypoid proliferation, should also be considered in the differential diagnosis. HLAs are commonly polypoid lesions, ranging from 0.5 cm to 3.5 cm. Microscopically, HLAs show proliferation of capillaries, veins, or lymphatics, involving the mucosa or submucosa only, and is not transmural. Vascular malformations are more common in women and grossly appear as “congestive streaks” that may range in size from 0.6 cm to 3 cm. Microscopically, they are composed of submucosal clusters of abnormal, variably sized vessels of different types, including arteries/arterioles, capillaries, veins/venules, and lymphatics. Mucosal ulceration or erosion is common in vascular malformation. Angiogenic polypoid proliferation of the small bowel typically occurs in the lamina propria and is not transmural; this was initially thought to be a paraneoplastic process of the mucosa surrounding small intestinal well-differentiated neuroendocrine tumors. However, Abraham et al. noted in a comparison cohort study that the researchers identified angiogenic polypoid proliferation in a majority of non-carcinoid neoplasms.[10] Thus, angiogenic polypoid proliferation is not specific to carcinoids. It can also occur in a variety of tumor types and seem to be rather an exaggerated form of mucosal prolapse.[10]

In summary, florid vascular proliferation is a benign pseudo-neoplastic vascular proliferation that may mimic other benign or malignant vascular lesions or neoplasms. Correct diagnosis of this entity is essential since this lesion is benign and does not appear to recur after complete surgical excision.[8]


Florid vascular proliferation usually is remarkable for an excellent prognosis after local surgical excision. In the most extensive series of five patients, no recurrences were seen with up to five-year follow-up postoperatively.[7][3]


Complete surgical excision is the treatment of choice. There are no reported complications in published English literature.[3]

Enhancing Healthcare Team Outcomes

Benign florid vascular proliferation is a rare entity with an excellent prognosis and no recurrence. The clinical presentation and symptoms are nonspecific. Radiological examination modalities such as barium enema, colonoscopy, and abdominal CT/MRI, are not very sensitive to make this diagnosis. A definitive diagnosis is only possible by tissue biopsy, and in most cases, the entire lesion excision with the microscopic examination is necessary, as the small biopsy material can be misleading. Microscopically, the lesion can mimic other benign or malignant vascular lesions. It is essential to render an accurate diagnosis for the subsequent treatment. Surgical resection is the mainstay of therapy and can monitor the patient as well as administer pain medication if needed.  A surgical nurse is a valuable asset before, during, and in the postoperative setting. The nurse should evaluate for concerning issues, assist with patient and family education, and coordinate follow-up care.  Oncology plays no role in the management of FVP since FVP is entirely a benign reactive process. An interprofessional approach will lead to better patient outcomes. [Level 5]



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Level 3 (low-level) evidence


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Level 3 (low-level) evidence


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Level 3 (low-level) evidence


Adachi S, Hamano R, Shibata K, Yoshida S, Tateishi H, Kobayashi T, Hanada M. Colonic lipoma with florid vascular proliferation and nodule-aggregating appearance related to repeated intussusception. Pathology international. 2005 Mar:55(3):160-4     [PubMed PMID: 15743326]

Level 3 (low-level) evidence


Park H, Park S, Hong YJ, Lee SW, Cho MS. Cytomegalovirus-associated intussusception with florid vascular proliferation in an infant. Journal of pathology and translational medicine. 2015 May:49(3):270-3. doi: 10.4132/jptm.2015.04.01. Epub 2015 May 15     [PubMed PMID: 26018521]


Agostini-Vulaj D, Whitney-Miller CL, Cellini C, Huber AR. Florid Vascular Proliferation of the Small Bowel and Colon, a Potential Masquerader of Malignancy: Report of Three Cases. International journal of surgical pathology. 2019 Sep:27(6):609-612. doi: 10.1177/1066896919837665. Epub 2019 Apr 3     [PubMed PMID: 30942096]

Level 3 (low-level) evidence


Gu MJ, Choi JH, Kim SH. Atypical florid vascular proliferation in appendix: a diagnostic dilemma. Diagnostic pathology. 2013 Jan 24:8():12. doi: 10.1186/1746-1596-8-12. Epub 2013 Jan 24     [PubMed PMID: 23347775]

Level 3 (low-level) evidence


Abrahams NA, Vesoulis Z, Petras RE. Angiogenic polypoid proliferation adjacent to ileal carcinoid tumors: a nonspecific finding related to mucosal prolapse. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2001 Sep:14(9):821-7     [PubMed PMID: 11557776]